肿瘤细胞死亡对细胞增殖的双重调控  

Dual regulation of tumor cell death on cell proliferation

作　　者：栾璐璐 董珊珊 王冉冉 李倩倩 曾勇 LUAN Lulu;DONG Shanshan;WANG Ranran;LI Qianqian;ZENG Yong(School of Pharmacy,University of South China,Hengyang,421001,Hunan,China;Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,410013,China)

机构地区：[1]南华大学药学院,湖南衡阳421001 [2]湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《肿瘤药学》2023年第5期533-541,共9页Anti-Tumor Pharmacy

基　　金：国家自然科学基金青年科学基金(81201730);湖南省自然科学基金(12JJ5073);湖南省科技厅重点研发项目(2018SK2126)。

摘　　要：细胞增殖和细胞死亡是控制整个生命体生长和发育的基本过程。癌症的特征是两者的异常调节导致细胞不受控制地持续增殖。最初,人们认为细胞死亡是一种常见的肿瘤抑制机制,这一特性被用于癌症治疗。然而,随着对细胞死亡越来越深入的了解,人们发现,死亡细胞可以促进肿瘤细胞增殖,进而导致肿瘤进展。因此,本文就几种不同的调节性细胞死亡(RCD)在肿瘤细胞增殖方面的研究现状进行简要综述,包括细胞凋亡、细胞焦亡以及自噬,并深入了解这些细胞死亡方式作为“双刃剑”如何通过细胞周期影响细胞增殖,以期为癌症的预防和治疗提供理论基础及新的思路。Cell proliferation and cell death are fundamental processes that control the growth and development of the whole living organisms.The abnormal regulation of cell proliferation and cell death result in the uncontrolled and continu‑ous proliferation of cells,which become the characteristic of cancer.Initially,it was thought that cell death was a common tumor suppressor mechanism,and this property was used in cancer therapy.However,with the increasing understanding of cell death,it has been found that dead cells can promote tumor cell proliferation,which in turn leads to tumor progression.Therefore,this article briefly reviewed the research status of several different regulatory cell death(RCD)in tumor cell pro‑liferation,including apoptosis,pyroptosis and autophagy,and summarized the in-depth understanding of how these cell death modes as a"double-edged sword"affect cell proliferation through the cell cycle,in order to provide theoretical basis and new ideas for the prevention and treatment of cancer.

关 键 词：细胞凋亡 细胞焦亡 细胞自噬 肿瘤细胞增殖 细胞周期 

分 类 号：R730[医药卫生—肿瘤]