“怪病多痰”病机观下抑郁症与慢性疲劳综合征的相关性  

Correlation Between Depression and Chronic Fatigue Syndrome under the Concept of“Strange Disease is Related to Phlegm”

作　　者：门奕年 黄珍 于明直 许心奕 雷超芳 刘玥芸 陈家旭 MEN Yinian;HUANG Zhen;YU Mingzhi;XU Xinyi;LEI Chaofang;LIU Yueyun;CHEN Jiaxu(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中医学院,北京100029

出　　处：《世界中医药》2023年第19期2777-2780,共4页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82174278)——逍遥散调控前额皮质Akt/GSK-3β/CRMP-2信号通路稳定神经元轴突起始节防治双相情感障碍的作用机制研究;北京市自然科学基金面上项目(7212182)——基于食欲中枢下丘脑的脾虚证肠道菌群失调机制研究。

摘　　要：抑郁症与慢性疲劳综合征是在症状上存在相似性,在发病机制上有潜在关联,并具有共同候选生物标志物和各自独特差异代谢物的异质性疾病。现聚焦抑郁症与慢性疲劳综合征的相似点,以“怪病多痰”为切入点,痰气交阻是二者相关的病机核心,脏腑功能失调-气机不利-化生痰浊-阻滞气机-伤及脏腑是二者的共同发病过程。在抑郁症与慢性疲劳综合征的研究和临证中,应重点关注“痰”与“气”的互作关系,以期更有效地将中医异病同治优势运用于慢性疑难性疾病的防治,并丰富其理论内涵。Depression and chronic fatigue syndrome are heterogeneous disorders that share similarities in symptoms and common candidate biomarkers,with unique differential metabolites.They have potential associations in pathogenesis mechanism.This paper focused on the similar characteristics of depression and chronic fatigue syndrome,and took“strange disease is related to phlegm”as the entry point.It was believed that phlegm-qi mutual obstruction was the common pathogenesis of these two diseases,and dysfunction of zang-fu organs-disorder of qi movement-turbid phlegm formation-blockage of qi movement-damage of zang-fu organs is the common disease pathway.In the research and clinical work of depression and chronic fatigue syndrome,we should emphasize the mutual relationship between“phlegm”and“qi”,to give full play of the advantages of traditional Chinese medicine in treating different diseases with the same method in the prevention and treatment of difficult chronic diseases and enrich the theoretical connotation.

关 键 词：怪病多痰 抑郁症 慢性疲劳综合征 痰证 精神障碍 躯体障碍 异病同治 痰气交阻 

分 类 号：R228[医药卫生—中医基础理论] R277.7[医药卫生—中医学]