DCE-MRI、DWI联合血清c-Met、MACC1对宫颈癌盆腔淋巴结转移的诊断价值  

Diagnostic value of dynamic contrast enhanced magnetic resonance imaging,diffusion-weighted imaging combined with serum c-Met and metastasis associated gene 1 in cervical cancer with pelvic lymph node metastasis

作　　者：李振玉 牛永超[2] 闫少华 万晓旻 LI Zhen-yu;NIU Yong-chao;YAN Shao-hua;WAN Xiao-min(Department of Imaging,Xinxiang Infectious Disease Hospital,Xinxiang 453000,Henan,CHINA;Department of Imaging,Xinxiang Central Hospital,Xinxiang 453000,Henan,CHINA)

机构地区：[1]新乡市传染病医院影像科,河南新乡453000 [2]新乡市中心医院影像科,河南新乡453000

出　　处：《海南医学》2023年第23期3446-3450,共5页Hainan Medical Journal

基　　金：河南省新乡市科技攻关计划项目(编号:GG2020042)。

摘　　要：目的探讨磁共振动态增强扫描成像(DCE-MRI)、磁共振弥散加权成像(DWI)联合血清人原癌基因编码蛋白(c-Met)、结肠癌转移相关基因1(MACC1)对宫颈癌盆腔淋巴结转移的诊断价值。方法回顾性分析2021年1月至2022年12月在新乡市中心医院诊治的100例宫颈癌患者的临床资料,按照是否出现盆腔淋巴结转移将患者分为转移组31例和未转移组69例,所有患者均做DCE-MRI、DWI检查和血清c-Met、MACC1检测。比较两组患者的DCE-MRI定量参数[血管外细胞外间隙容积分数(Ve)、容量转移常数(K_(trans))与速率常数(K_(ep))]、平均表观扩散系数(ADC)值及血清c-Met、MACC1水平,计算并比较DCE-MRI、DWI与血清c-Met、MACC1单独及联合诊断宫颈癌盆腔淋巴结转移的准确度、特异度、灵敏度。结果两组患者的Ve比较差异无统计学意义(P>0.05);转移组患者的K_(trans)、K_(ep)分别为(0.30±0.07)/min、(0.47±0.06)/min,明显高于未转移组的(0.22±0.05)/min、(0.43±0.07)/min,平均ADC值为0.82±0.15,明显低于未转移组的1.33±0.24,差异均有统计学意义(P<0.05);转移组患者的c-Met、MACC1水平分别为(127.53±27.48)μg/L、(9.24±3.01)ng/mL,明显高于未转移组的(81.25±18.75)μg/L、(5.21±1.37)ng/mL,差异均具有统计学意义(P<0.05);DCE-MRI、DWI与血清c-Met、MACC1四者联合诊断宫颈癌盆腔淋巴结转移的准确度、特异度、灵敏度均明显高于四者单独诊断,差异均具有统计学意义(P<0.05)。结论DCE-MRI、DWI联合血清c-Met、MACC1对宫颈癌盆腔淋巴结转移的诊断价值较高。Objective To investigate the diagnostic value of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI),diffusion-weighted imaging(DWI)combined with serum human proto-oncogene coding protein(c-Met)and metastasis-associated gene 1 in colon cancer(MACC1)in cervical cancer with pelvic lymph node metastasis of cervical cancer.Methods The clinical data of 100 patients with cervical cancer diagnosed and treated in Xinxiang Central Hospital from January 2021 to December 2022 were retrospectively analyzed.They were divided into metastatic group(31 cases)and non-metastatic group(69 cases)according to whether pelvic lymph node metastasis occurred.All patients underwent DCE-MRI,DWI,serum c-Met and MACC1 detection.Quantitative parameters of DCE-MRI[including extravascular extracellular space volume fraction(Ve),volume transfer constant(K_(trans)),and the rate constant(K_(ep))],average apparent diffusion coefficient(ADC),and serum c-Met and MACC1 levels were compared between the two groups.The accuracy,specificity,and sensitivity of DCE-MRI,DWI,serum c-Met and MACC1 alone and in combination in the diagnosis of cervical cancer with pelvic lymph node metastasis were calculated and compared.Results There was no significant difference in Ve between the two groups(P>0.05).The values of K_(trans)and K_(ep)in the metastatic group were(0.30±0.07)/min and(0.47±0.06)/min,which were significantly higher than(0.22±0.05)/min and(0.43±0.07)/min in the non-metastatic group,and the average ADC value was 0.82±0.15,significantly lower than 1.33±0.24 in the non-metastatic group(P<0.05).The levels of c-Met and MACC1 in the metastatic group were(127.53±27.48)μg/L and(9.24±3.01)ng/mL,which were significantly higher than(81.25±18.75)μg/L and(5.21±1.37)ng/mL in the non-metastatic group(P<0.05).The accuracy,specificity,and sensitivity of DCE-MRI,DWI,serum c-Met,and MACC1 in combination in the diagnosis of cervical cancer with pelvic lymph node metastasis were significantly higher than those of each index alone,and the differences w

关 键 词：宫颈癌 盆腔淋巴结转移 动态增强扫描成像 弥散加权成像 人原癌基因编码蛋白 结肠癌转移相关基因1 诊断价值 

分 类 号：R737.33[医药卫生—肿瘤]