源于动物类中药活性肽药理作用研究进展  

Research Progress on Pharmacological Action of Active Peptides Derived from Animal Traditional Chinese Medicine

作　　者：刘长龙[1] 李云霄 张红艳[1] 金保东 刘丽达[1] 高鹏[3] LIU Chang-long;LI Yun-xiao;ZHANG Hong-yan;JIN Bao-dong;LIU Li-da;GAO Peng(Pharmacy Department of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China;Pharmacy Department of Endocrine and Metabolic Hospital Affiliated to Shandong First Medical University,Jinan 250002,Shandong,China;Pharmacy College of Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China)

机构地区：[1]山东中医药大学第二附属医院药学部,山东济南250000 [2]山东第一医科大学附属内分泌与代谢病医院药剂科,山东济南250002 [3]山东中医药大学药学院,山东济南250355

出　　处：《医学信息》2023年第24期173-177,192,共6页Journal of Medical Information

基　　金：山东省重大科技创新工程项目(编号:2019JZZY020906)。

摘　　要：本文对近年来源于动物类中药活性肽药理作用研究进展进行综述,以期为动物类中药活性肽的开发利用以及探寻生物活性成分提供新思路。本文以2020版《中国药典》中收录及临床常用的40余种动物类中药为关键字,查阅整理近年来国内外相关文献报道,从抗凝、调节血脂、抗肿瘤、抗氧化、保肝等方面阐述动物类中药活性肽的药理作用。活性肽分子量一般小于5 KDa,相比于蛋白质、大分子多肽和氨基酸,更容易被人体吸收,且具有多种生理活性,表明动物类中药活性肽具有较高的研究和开发价值。This article reviews the research progress of active peptide derived from animal traditional Chinese medicine in recent years.It provides a new idea for the development and utilization of active peptide from animal traditional Chinese medicine.With more than 40 animal traditional Chinese medicines in the 2020 edition of the Chinese Pharmacopoeia and commonly used in clinic as the key words,we have reviewed and collated relevant literature reports at home and abroad in recent years,the pharmacological effects of active peptides from animal traditional Chinese medicine on anticoagulation,regulation of Blood Lipid,anti-tumor,anti-oxidation and protection of liver are expounded.The relative molecular weight of active peptides is generally less than 5 KDa,which is easier to be absorbed by human body than protein,macromolecular peptides and amino acids.Meanwhile,it has many kinds of physiological activities,which indicates that the active peptides of animal traditional Chinese medicine have high research and development value.

关 键 词：中药 活性肽 动物类中药 药理作用 

分 类 号：R285[医药卫生—中药学]