血清骨钙素水平和骨密度与帕金森病患者伴抑郁状态的相关性研究  

Correlations of serum osteocalcin level and bone mineral density with depression status in patients with Parkinson′s disease

作　　者：周曼曼 徐志强[2] 高雯雯 李毅娣 付娟 杨改清[2] ZHOU Manman;XU Zhiqiang;GAO Wenwen;LI Yidi;FU Juan;YANG Gaiqing(Xinxiang Medical College,Xinxiang,Henan,453003;Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan,450000)

机构地区：[1]新乡医学院,河南新乡453003 [2]郑州大学附属郑州市中心医院神经内科,河南郑州450000

出　　处：《实用临床医药杂志》2023年第21期125-130,共6页Journal of Clinical Medicine in Practice

基　　金：河南省医学科技攻关计划项目(192102310082,LHGJ20191042)。

摘　　要：目的探讨血清骨钙素(OCN)水平、骨密度(BMD)与帕金森病(PD)患者伴抑郁状态的相关性。方法回顾性选取66例PD患者(PD组)和49例健康体检者(健康对照组)作为研究对象,比较2组一般资料、血清OCN水平、腰椎及左侧股骨颈BMD。根据汉密尔顿抑郁量表-17(HAMD-17)评分将PD患者分为PD伴抑郁状态组41例和PD不伴抑郁状态组25例,比较2组患者一般资料、血清OCN水平、腰椎及左侧股骨颈BMD。采用Pearson相关分析法探讨血清OCN水平、腰椎及左侧股骨颈BMD与PD患者抑郁评分、焦虑评分的相关性。采用多因素Logistic回归分析明确PD患者伴抑郁状态的影响因素。结果PD组血清OCN水平、腰椎及左侧股骨颈BMD低于健康对照组,差异有统计学意义(P<0.05);PD伴抑郁状态组血清OCN水平、腰椎及左侧股骨颈BMD低于PD不伴抑郁状态组,差异有统计学意义(P<0.05)。PD患者血清OCN水平、腰椎BMD、左侧股骨颈BMD均分别与抑郁评分、焦虑评分显著相关(P<0.05)。血清OCN水平降低、腰椎BMD降低、左侧股骨颈BMD降低均为PD患者伴抑郁状态的独立危险因素(P<0.05)。结论血清OCN水平、腰椎BMD、左侧股骨颈BMD均与PD患者伴抑郁状态密切相关,这或可为PD患者抑郁的临床防治提供参考。Objective To investigate the correlations of serum osteocalcin(OCN)level and bone mineral density(BMD)of depression status in Parkinson's disease(PD)patients with depression.Methods A total of 66 patients with PD(PD group)and 49 healthy people(healthy control group)were selected as study objects.The general clinical data,serum OCN level,BMD of lumbar spine and left femoral neck between two groups were compared.According to Hamilton Depression Scale-17(HAMD-17)score,PD patients were divided into PD with depression group(n=41)and PD without depression group(n=25).The general clinical data,serum OCN level,BMD of lumbar spine and left femoral neck were compared between the two groups.Pearson correlation analysis was used to investigate the correlations of serum OCN level,BMD of lumbar spine and left femoral neck with depression score and anxiety score of PD patients.Multivariate Logistic regression analysis was used to determine the influencing factors of PD patients with depression.Results Compared with healthy control group,serum OCN level and BMD of lumbar spine and left femoral neck in the PD group were significantly decreased(P<0.05).The level of serum OCN and BMD of lumbar spine and left femoral neck in the PD with depression group were significantly lower than those in the PD without depression group( P <0.05). Serum OCN level, BMD of lumbar spine and left femoral neck in PDpatients were significantly correlated with depression and anxiety scores ( P <0.05). Decreased serum OCN leveland decreased BMD in lumbar spine and left femoral neck were independent risk factors for PD with depression ( P<0.05). Conclusion Serum OCN level, BMD of lumbar spine and BMD of left femoral neck are closely related toPD patients with depression, which may provide a reference for the clinical prevention and treatment of depressionin PD patients.

关 键 词：帕金森病 骨钙素 骨密度 抑郁 焦虑 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R681[医药卫生—临床医学]