基于PET/CT的肺腺癌多模式诊断及预后价值  

Multimodal diagnosis and prognostic value of lung adenocarcinoma based on PET/CT

作　　者：刘莉娜[1] 陈佳佳[1] 臧玮娜[1] 刘艺 姜雪莲 关建中[1] LIU Lina;CHEN Jiajia;ZANG Weina;LIU Yi;JIANG Xuelian;GUAN Jianzhong(Department of Nuclear Medicine,No.971st Hospital of PLA,Qingdao 266071,China)

机构地区：[1]中国人民解放军第九七一医院核医学科,山东青岛266071

出　　处：《医学影像学杂志》2023年第11期1994-1997,共4页Journal of Medical Imaging

摘　　要：目的探讨基于PET/CT的肺腺癌多模式诊断及预后价值。方法选取69例肺腺癌患者,行PET/CT扫描及胸部薄层CT扫描,根据胸部薄层CT、PET图像、PET图像联合胸部薄层CT三种不同方法对肺腺癌进行诊断。结果69例肺腺癌有21例高分化腺癌,35例中分化腺癌,13例低分化腺癌。中分化肺腺癌的SUVmax(mean=5.57±3.08,n=35)明显高于高分化肺腺癌(mean=2.79±2.68,n=21),差异有统计学意义(t’=-3.55,P=0.001<0.01)。低分化肺腺癌的SUVmax(mean=6.48±4.04,n=13)明显高于高分化肺腺癌(mean=2.79±2.68,n=21),差异有统计学意义(t’=-2.93,P=0.009<0.01)。8年以下生存期的SUVmax(mean=6.39±3.11,n=34)明显高于8年以上生存期的SUVmax(mean=3.43±3.13,n=35),差异有统计学意义(t’=3.94,P=0.000<0.01)。5年以下生存期的SUVmax(mean=6.25±3.50,n=24)明显高于5年以上生存期(mean=4.17±3.22,n=45),差异有统计学意义(t’=2.42,P=0.02<0.05)。结论结合肺腺癌的形态学及代谢特点,PET图像联合胸部薄层CT多模式诊断能够提高肺腺癌的诊断准确率,还能够为肺腺癌的病理分级和患者的生存期的预测提供帮助。Objective To investigate the value of multimodal diagnosis and prognosis of lung adenocarcinoma based on PET/CT.Methods PET/CT scan and chest thin-slice CT scan were performed in 69 cases of lung adenocarcinoma confirmed by pathology and followed up for more than 8 years.According to three different methods of chest thin-slice CT,PET image,PET image combined with chest thin-slice CT,the diagnostic efficiency of the three imaging methods was compared.Results Among 69 cases of lung adenocarcinoma,21 cases were well differentiated adenocarcinoma,35 cases were moderately differentiated adenocarcinoma and 13 cases were poorly differentiated adenocarcinoma.There were 55 cases with short spicule,50 cases with lobulation or light lobulation,28 cases with rough edge,9 cases with vacuole sign,4 cases with bronchial vascular bundle sign,2 cases with air bronchial sign,and 1 case with pleural tail sign.SUVmax of moderately differentiated lung adenocarcinoma(mean=5.57±3.08,n=35)was significantly higher than that of well differentiated lung adenocarcinoma(mean=2.79±2.68,n=21),with statistical significance(t'=-3.55,P=0.001<0.01).SUVmax of poorly differentiated lung adenocarcinoma(mean=6.48±4.04,n=13)was significantly higher than that of well differentiated lung adenocarcinoma(mean=2.79±2.68,n=21),with statistical significance(t'=-2.93,P=0.009<0.01).The SUVmax of survival time under 8 years(mean=6.39±3.11,n=34)was significantly higher than that of survival time over 8 years(mean=3.43±3.13,n=35),and there was statistical significance(t'=3.94,P=0.000<0.01).The SUVmax of survival time under 5 years(mean=6.25±3.50,n=24)was significantly higher than that of survival time over 5 years(mean=4.17±3.22,n=45),with statistical significance(t'=2.42,P=0.02<0.05).60 cases of lung adenocarcinoma were correctly diagnosed by chest thin-slice CT,the accuracy was 87.0%;49 cases of lung adenocarcinoma were correctly diagnosed by PET image,with the accuracy of 71.0%;67 cases of lung adenocarcinoma were correctly diagnosed by PET image combin

关 键 词：肺腺癌 多模式诊断 预后评估 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]