α-突触核蛋白在帕金森病发病机制中的研究进展  

Research progress ofα-synuclein in the pathogenesis of Parkinson's disease

作　　者：刘柯婷 贺泽民 杨百元[1] 钟成清 苟伟[1] 肖莉[3] LIU Ke-ting;HE Ze-min;YANG Bai-yuan;ZHONG Cheng-qing;GOU Wei;XIAO Li(Department of Neurology,Chengdu Seventh People's Hospital,Chengdu Sichuan 610213,China;Department of Thoracic Surgery,West China(Airport)Hospital Sichuan University,Chengdu Sichuan 610200,China;Department of Human Anatomy and Histoembryology,Development and Regeneration Key Laboratory of Sichuan Province,Chengdu Medical College,Chengdu Sichuan 610500,China)

机构地区：[1]成都市第七人民医院神经内科,四川成都610213 [2]四川大学华西空港医院胸外科,四川成都610200 [3]成都医学院人体解剖与组织胚胎学教研室/发育与再生四川省重点实验室,四川成都610500

出　　处：《局解手术学杂志》2023年第12期1091-1094,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：成都医学院院校联合基金(2021LHJYPJ-07);成都市科研课题(2022103,2022307);四川省教育厅项目(18ZB0179)。

摘　　要：帕金森病(PD)是最常见的神经系统退行性疾病,路易小体(LBs)是其最典型的病理改变。LBs的主要成分是α-突触核蛋白(α-syn),其被认为是PD的致病因子。传递假说认为,病理性α-syn可由受损神经元转运到正常神经元,导致受体神经元中α-syn也产生病理性错误折叠和聚集,导致级联式神经细胞受损。肠脑轴假说认为,病理性α-syn可由肠道产生,经由迷走神经上传至中枢神经系统。本文就α-syn在PD发病机制中的作用进行概述,以期为PD的干预靶点的研究提供参考。Parkinson's disease(PD)is the most common neurodegenerative disease,and Lewy bodies(LBs)is the most typical pathological change.α-synuclein(α-syn),as the main component of LBs,is considered as the pathogenic factor of PD.According to the transmission hypothesis,pathologicalα-syn can be transported from damaged neurons to normal neurons,leading to pathological misfolding and aggregation ofα-syn in recipient neurons,resulting in cascading neuronal damage.According to the hypothesis of gut-brain axis,pathologicalα-syn can be produced in the intestine,and uploaded to the central nervous system via the vagus nerve.In this paper,the role ofα-syn in the pathogenesis of PD is summarized,in order to provide reference for the study of intervention targets of PD.

关 键 词：帕金森病 Α-突触核蛋白 肠脑轴 

分 类 号：R742.5[医药卫生—神经病学与精神病学]