线粒体能量代谢相关铁死亡在肿瘤治疗中的研究进展  

Recent Progress of Mitochondrial Energy Metabolism-related Ferroptosis in Tumor Therapy

作　　者：吉士俊 刘楠[1] JI Shi-jun;LIU Nan(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198

出　　处：《药物生物技术》2023年第5期525-530,共6页Pharmaceutical Biotechnology

摘　　要：传统的癌症治疗往往伴随着严重的耐药性问题。铁死亡是新发现的以铁积累和脂质过氧化为主要特征的非凋亡性细胞死亡形式。由于肿瘤细胞对铁依赖性提高,诱导肿瘤细胞铁死亡成为一种很有前景的治疗方式。线粒体稳态及其能量代谢过程可调节不同铁死亡途径,进而影响肿瘤细胞的发生发展过程。本文从线粒体形态功能和能量代谢的主要途径,及其对铁死亡功能的影响进行综述,进一步阐明线粒体能量代谢调控铁死亡的机制,为相关疾病的临床研究提供依据。Traditional cancer treatments are often accompanied by serious drug resistance problems.Ferroptosis is a newly discovered form of non-apoptotic regulated cell death,which is characterized by iron accumulation and lipid peroxidation.As increased iron dependence of tumor cells,inducing ferroptosis of tumor cells was a promising therapeutic approach.Mitochondrial homeostasis and its energy metabolism play an important role in the regulation of ferroptosis,thus affecting the occurrence and developments of tumor cells.The main pathways of mitochondrial morphology and function,energy metabolism and their effects on ferroptosis were reviewed in this paper.The mechanism of mitochondrial energy metabolism regulating ferroptosis was further elucidated,which provided the evidence for clinical research of related diseases.

关 键 词：线粒体 能量代谢 铁死亡 氧化磷酸化 活性氧 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]