儿童癫痫与维生素D相关性研究进展  

Research progress on the relationship between pediatric epilepsy and vitamin D

作　　者：李晨豪 喻喜华 闫文浩 柴宇霞[1] 李燕燕 李锟[3] 李泽运 LI Chenhao;YU Xihua;YAN Wenhao;CHAI Yuxia;LI Yanyan;LI Kun;LI Zeyun(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China;SINOPHARM Xingsha Pharmaceuticals(Xiamen)Co.,Ltd.,Xiamen 361000,Fujian,China;Huanghe Science and Technology College,Zhengzhou 450063,Henan,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450052 [2]国药控股星鲨制药(厦门)有限公司,福建厦门361000 [3]黄河科技学院,河南郑州450063

出　　处：《中国临床药理学与治疗学》2023年第11期1299-1306,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：河南省科技攻关项目(222102310388);河南省高等学校重点科研项目(22B350002)。

摘　　要：癫痫是一种由于脑部神经元异常放电引起的临床综合征,具有长期、缓慢、反复、多病因、多临床表现等特点。其机制复杂,危害巨大,可造成不可逆的脑功能损伤甚至死亡。儿童癫痫发病率约为成人2倍,我国约有650万儿童癫痫患者,严重危害儿童生长发育与健康。研究发现维生素D水平与儿童癫痫的发生、发展、治疗等密切相关:首先,癫痫本身可能改变儿童活动、饮食等而影响维生素D水平;其次,抗癫痫发作药物治疗可能诱导肝药酶加速维生素D代谢引起其水平降低;同时,抗癫痫发作药物种类、合用、用药时长等因素与维生素D降低相关;另一方面,维生素D补充可能对儿童抗癫痫治疗具有一定的裨益。近年来就以上问题国内外进行了大量临床研究,然而结论仍未明确。作者回顾近年来儿童癫痫与维生素D相关性的临床研究,旨在就儿童癫痫疾病与维生素D水平相关性进行系统梳理,以期指导临床合理用药。Epilepsy is a long-term,chronic,recurrent,multi-factorial,multi-symptomatic nervous system disease,and was caused by abnormal discharge of brain neurons.Etiology can cause irreversible brain dysfunction and even death.There are about 6.5 million children with epilepsy in China,with incidence rate twice that of adult,presenting serious threaten to children's growth and development.Vitamin D has been well-known for crucial importance to development of nervous,skeletal,and immune system.Studies have found that pediatric epilepsy as well as other neurological diseases were closely related with vitamin D deficiency.First,a large number of studies have shown that vitamin D in children with epilepsy is affected by epilepsy itself;second,the use of anti-seizure medicines can alter metabolism of vitamin D by inducing cytochrome oxidases;third,the inducement was concerned to varieties,combination and duration of anti-seizure medicines;fourth,it was expected that supplement of vitamin D during antiepileptic treatment would guarantee an improvement of treating given that anti-seizure medicines may lead to deficiency of vitamin D.Large numbers of researches have reported on the correlation ship between pediatric epilepsy and vitamin D.However,there is still a lack of systematic review.This article aims to retrospect the research progress of relationship between pediatric epilepsy and vitamin D,and provide valuable feedbacks on further treatment of pediatric epilepsy.

关 键 词：儿童癫痫 维生素D 相关性 研究进展 抗癫痫发作药物 

分 类 号：R748[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]