两湖地区肺癌人群MICA基因分布比较分析  

Comparative analysis of MICA gene distribution in lung cancer population of Hunan and Hubei

作　　者：陈慧 陈纯静 李育萌 陈恩 CHEN Hui;CHEN ChunJing;LI Yumeng;CHEN En(Department of Record room,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan,China;Hunan University of Chinese Medicine,Changsha,Hunan,China;Department of Laboratory Medicine,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan,China)

机构地区：[1]南华大学附属第一医院病案室,湖南衡阳421001 [2]湖南中医药大学,湖南长沙410208 [3]南华大学附属第一医院检验医学中心,湖南衡阳421001

出　　处：《实验与检验医学》2023年第4期379-382,387,共5页Experimental and Laboratory Medicine

基　　金：湖南省自然科学基金资助,编号2021JJ70038,2022JJ40396。

摘　　要：目的研究两湖地区中荆州和衡阳肺癌人群MICA等位基因分布差异。方法采用PCR-SSP和PCR-SBT方法对样本MICA等位基因的多态性进行检测。结果衡阳组和荆州组各检出8种MICA等位基因,其中衡阳组中未检出MICA*027,荆州组中未检出MICA*009N;荆州患者组中分布频率最高的3种等位基因是MICA*00201、MICA*019和MICA*010;衡阳患者组中分布频率最高的3种等位基因是MICA*010、MICA*00201和MICA*01201;两组之间MICA等位基因分布间存在统计学差异。衡阳组和荆州组检出的MICA等位基因型、MICA-STR等位基因分布频率和MICA-STR等位基因型均不相同,但分布总体比较无统计学差异(P>0.05)。结论两湖地区肺癌人群MICA等位基因频率分布之间存在差异。Objective To study the difference of MICA allele distribution in Jingzhou and Hengyang.Methods The sample MICA allele was detected by PCR-SSP and PCR-SBT.Results Eight MICA alleles were detected in Hengyang group and Jingzhou group,MICA*027 was not detected in Hengyang group,MICA*009N in Jingzhou group,the three alleles in Jingzhou patient group were MICA*00201 and MICA*019 and MICA*and the 3 alleles in Hengyang patient group were MICA*010,MICA*00201 and MICA*01201 and MICA alleles between the two groups.The MICA allele type,MICA-STR allele distribution frequency and MICA-STR allele type detected in Hengyang group and Jingzhou group were all different,but the overall distribution was not significantly different(P>0.05).Conclusion MICA allele frequency distribution varies between lung cancer population of Hunan and Hubei.

关 键 词：MICA基因 基因多态性 肺癌 两湖地区 

分 类 号：R734.2[医药卫生—肿瘤]