Postoperative mometasone irrigations improve quality of life in skull base tumor patients  

作　　者：Mandy K.Salmon Rijul S.Kshirsagar Jacob G.Eide Auddie M.Sweis Kathleen Davin Aman Prasad Heather Ungerer Elizabeth Stevens Kevin Ig‐Izevbekhai Siddhant Tripathi Tran B.Locke Theodore Lin Brian M.Sweis Michael A.Kohanski Nithin D.Adappa James N.Palmer 

机构地区：[1]Department of Otorhinolaryngology—Headand Neck Surgery,University of Pennsylvania,Philadelphia,Pennsylvania,USA [2]Division of Otolaryngology—Head and Neck Surgery,North Shore University Health System,The University of Chicago,Evanston,Illinois,USA [3]University of Cincinnati School of Medicine,Cincinnati,Ohio,USA [4]Department of Otolaryngology,Baylor College of Medicine,Houston,Texas,USA [5]Lewis Katz School of Medicine,Temple University,Philadelphia,Pennsylvania,USA [6]Department of Neuroscience,University ofMinnesota,Minneapolis,Minnesota,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2023年第4期314-319,共6页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objectives:The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied.We quantified long‐term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS.Methods:Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019.Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected.Preoperative,and 1‐,3‐,6‐,12‐,18‐,and 24‐month postoperative Sino‐Nasal Outcome Test (SNOT‐22) scores were assessed.Results:A total of 727 patients were assessed (53.4% males),with 479 patients in the no SI group and 248 patients in the SI group.Preoperative SNOT‐22 scores did not differ significantly (P = 0.19).1‐,3‐,6‐,12‐,18‐,and 24‐month post‐op SNOT‐22 scores did not significantly differ between groups.However,mometasone irrigations resulted in significantly lower postoperative 2‐year SNOT‐22 scores compared to budesonide (P < 0.01) and saline (P = 0.03).Conclusions:Though corticosteroid irrigations are routine in managing inflammatory sinus disease,their role in postoperative management after ESBS for tumors is unclear.Our findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS.

关 键 词：postoperative steroid irrigations skull base tumors 

分 类 号：R739.4[医药卫生—肿瘤]