阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的临床价值  

Clinical Value of Atorvastatin Calcium in Treatment of Cognitive Dysfunction after Cerebral Infarction

作　　者：董晓光[1] 丁希艳[1] 李彦冬[1] DONG Xiaoguang;DING Xiyan;LI Yandong(Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2024年第1期71-75,共5页Journal of Beihua University（Natural Science）

基　　金：吉林省科技发展计划项目(YDZJ202201ZYTS156)。

摘　　要：目的探讨阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的临床价值。方法对80例脑梗死后认知功能障碍患者随机分为试验组和对照组,每组40例。对照组行常规治疗,试验组行阿托伐他汀钙辅助治疗。比较两组患者治疗后的临床治疗效果,观察评价两组患者的认知功能障碍、生活自理能力、血脂水平、并发症发生情况。结果治疗后,试验组患者的临床疗效明显优于对照组(P<0.05);治疗后,两组患者的认知功能评分试验组明显优于对照组,试验组生活自理能力明显高于对照组,TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组(均P<0.05);治疗后,两组患者的并发症发生情况试验组明显低于对照组(P<0.05)。结论对脑梗死后认知功能障碍患者实施阿托伐他汀钙辅助治疗,可有效改善患者的认知功能障碍,提升生活自理能力,改善患者的血脂水平,降低并发症发生,在临床上具有较高的推广应用价值。Objective To investigate the clinical value of atorvastatin calcium in the treatment of cognitive dysfunction after cerebral infarction.Method 80 patients with cognitive dysfunction after cerebral infarction were randomly divided into observation group and control group with 40 cases in each group.The control group received routine treatment,and the observation group received atorvastatin calcium adjuvant therapy.The clinical therapeutic effects of the two groups were compared,and the cognitive dysfunction,self-care ability,blood lipid level and complications of the two groups were observed and evaluated.Results Compared with the control group,the clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the cognitive function score of the observation group was significantly better than that of the control group,the self-care ability of the observation group was significantly higher than that of the control group,the levels of TC,TG and LDL-C were lower than those of the control group,and the levels of HDL-C were higher than those of the control group(all P<0.05).After treatment,the incidence of complications in the two groups was significantly lower than that in the control group(P<0.05).Conclusion Atorvastatin calcium adjuvant therapy for patients with cognitive dysfunction after cerebral infarction can effectively improve their cognitive dysfunction,improve their self-care ability,improve their blood lipid level,and reduce the occurrence of complications,which has high clinical application value.

关 键 词：阿托伐他汀钙 脑梗死 认知功能障碍 血脂水平 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]