调节性细胞死亡在炎症性肠病中的研究进展  

Research progress of regulated cell death in inflammatory bowel disease

作　　者：高西壮 杨永红[2] 于伟 朱凤琴 周广玺 Gao Xizhuang;Yang Yonghong;Yu Wei;Zhu Fengqin;Zhou Guangxi(Clinical Medicine College,Jining Medical University,Jining 272067,China;Medical Research Center,the Affiliated Hospital of Jining Medical University,Jining 272029,China;Department of Gastroenterology,the Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,济宁272067 [2]济宁医学院附属医院医学研究中心,济宁272029 [3]济宁医学院附属医院消化内科,济宁272029

出　　处：《中华炎性肠病杂志（中英文）》2023年第4期365-370,共6页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(82270562、82200591、81901655);山东省泰山青年学者基金(tsqn202103190)。

摘　　要：炎症性肠病(IBD)是一种慢性肠道炎症性疾病,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。随着调节性细胞死亡在IBD中的研究深入,越来越多的证据表明自噬、铁死亡、细胞焦亡、凋亡和坏死性凋亡与IBD的进展以及转归密切相关。本文综述了以自噬为代表的调节性细胞死亡在IBD中的发病机制以及治疗前景,为IBD的治疗提供参考。Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease,mainly including ulcerative colitis(UC)and Crohn′s disease(CD).With the in-depth study of the role of regulated cell death(RCD)in IBD,more and more evidences show that autophagy,ferroptosis,pyroptosis,apoptosis and necroptosis are closely related to the progress and prognosis of IBD.This article reviews the pathogenesis and therapeutic prospects of RCD represented by autophagy in IBD,providing a reference for the treatment of IBD.

关 键 词：炎症性肠病 调节性细胞死亡 自噬 铁死亡 细胞焦亡 凋亡 坏死性凋亡 

分 类 号：R574[医药卫生—消化系统]