加减归脾汤治疗cblC型甲基丙二酸尿症心脾两虚证语言发育迟缓患儿随机对照研究  

Modified Guipi Decoction in Treatment of Language Development Disorders in cblC Type Methylmalonic Aciduria Children with Xin-Pi Deficiency Syndrome:A Randomized Controlled Trial

作　　者：李甜馨 郑宏[2] 陈永兴 卫海燕[3] 陆相朋 冯斌[2] 冯刚[2] 党伟利[2] 张璠[2] 靳辉 张弛[2] 李佩倩 LI Tian-xin;ZHENG Hong;CHEN Yong-xing;WEI Hai-yan;LU Xiang-peng;FENG Bin;FENG Gang;DANG Wei-li;ZHANG Fan;JIN Hui;ZHANG Chi;LI Pei-qian(Pediatric Medical College,Henan University of Chinese Medicine,Zhengzhou,450000;Department of Pediatrics,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,450000;Depatment of Endocrinology,Genetics and Metabolism,Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,450053)

机构地区：[1]河南中医药大学儿科医学院,郑州450000 [2]河南中医药大学第一附属医院儿科,郑州450000 [3]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院内分泌遗传代谢科,郑州450053

出　　处：《中国中西医结合杂志》2023年第11期1321-1326,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金青年科学基金项目(No.82104929);国家中医临床研究基地科研专项(No.2019JDZX2056);河南省中医药科学研究专项课题(No.20-21ZY2110)。

摘　　要：目的观察加减归脾汤治疗cblC型甲基丙二酸尿症(MMA)心脾两虚证语言发育迟缓患儿的疗效。方法将61例cblC型MMA心脾两虚证语言发育迟缓患儿随机分为试验组(31例)和对照组(30例)。两组均在接受西医基础治疗和言语训练的基础上,试验组给予加减归脾汤颗粒,对照组给予加减归脾汤模拟剂颗粒,总疗程为12周。基于中医证候疗效积分、S-S语言发育迟缓检查法比较两组疗效。结果与对照组同期比较,治疗后试验组的有效率高,神思涣散、面色少华、神疲乏力、食少纳差、多梦不安、大便不调的中医症状积分降低(P<0.05),交流态度良好、语言理解能力高阶段例数增加(P<0.05)。治疗过程中未发现明显不良反应。结论加减归脾汤可有效改善cblC型MMA心脾两虚证患儿的交流态度、语言理解功能及神思涣散、面色少华、神疲乏力、食少纳差、多梦不安、大便不调的临床症状,并对患儿动作性课题、语言表达功能的提升有一定效果。(研究注册编号:ChiCTR2100044682)Objective To observe the clinical efficacy of modified Guipi Decoction(MGD)in treatment of language development disorders in cblC type methylmalonic aciduria(MMA)children with Xin-Pi deficiency syndrome.Methods Totally 61 language development disorders in cblC type MMA children with XinPi deficiency were randomly assigned to the experimental group(31 cases)and the control group(30 cases).All children received basic treatment of Western medicine and speech training.Patients in the experimental group took MGD,while those in the control group took MGD simulant granules.After 12 weeks of treatment,the efficacy of 2 groups were compared based on Chinese medicine(CM)syndrome score and S-S language development disorders.Results Compared with the control group in the same period,effective rate increased,the scores of CM syndromes of inattention,pale complexion,fatigue,poor appetite,restless dreams,and irregular stool decreased(P<0.05),and the number of cases with good communication attitude and in the high stage of language comprehension increased after treatment in the experimental group(P<0.05).No serious adverse events occurred during the treatment course.Conclusion MGD could effectively improve the communication attitude,language understanding function and clinical symptoms of cblC type MMA children with Xi-Pi deficiency including laxity of mind,pale complexion,fatigue,poor appetite,restless dreams,and irregular stool,and have a certain effect on children's movement problems and language expression function.(Trial Registration:No.ChiCTR210044682).

关 键 词：甲基丙二酸尿症 儿童 语言发育迟缓 归脾汤 中药复方 中西医结合 

分 类 号：R272[医药卫生—中医儿科学]