人工智能在宫颈癌近距离治疗中应用的研究进展  

Application of artificial intelligence in brachytherapy for cervical cancer

作　　者：张文君 张杰[1] 罗春丽[1] 刘楠[1] 于浪[1] 邱杰[1] Zhang Wenjun;Zhang Jie;Luo Chunli;Liu Nan;Yu Lang;Qiu Jie(Department of Radiation Oncology,Chinese Academy of Medical Sciences,Peking Union Medical College,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院放疗科,北京100730

出　　处：《中华放射肿瘤学杂志》2023年第12期1109-1113,共5页Chinese Journal of Radiation Oncology

基　　金：中央高水平医院临床科研项目(2022-PUMCH-B-052);中央高水平医院临床科研青年培优计划项目(2022-PUMCH-A-101)。

摘　　要：近距离治疗(BT)技术是使放射源进入或贴近治疗部位, 利用近源处剂量极高随着距离的增加剂量快速跌落, 实现肿瘤局部治疗的一种技术。近距离治疗是宫颈癌放射治疗的重要组成部分。近距离治疗过程复杂且需要一系列步骤, 可能导致患者在施源器置入状态下等待时间过长而产生施源器相对于肿瘤的位置以及器官充盈状态的改变。近些年, 人工智能(AI)在医学领域有了极大的发展, 机器学习以及神经网络等模型广泛应用于近距离治疗的各个环节, 如施源器置入、图像采集、靶区和危及器官勾画、施源器重建、剂量优化和治疗实施等步骤。在缩短流程总体耗时、提高操作同质性及提高治疗精度等方面作用显著。本文总结了近年来AI在宫颈癌近距离治疗中的应用、发展前景以及面临的挑战, 对AI在临床近距离治疗中的应用进行展望并提供新的思路。Brachytherapy(BT)provides the opportunity to deliver highly potent radiation doses to the tumor,while more effectively sparing the surrounding organs at risk(OAR)due to the proximity of radiation sources to the tumor target and rapid fall-off of the source dose profile.As an important part of radiotherapy for cervical cancer,BT plays an irreplaceable role.The BT process is complex and can be divided into a series of steps.Long time waiting for patients in the state of implantation of the applicator may cause changes in the position of the applicator relative to the tumor and the movement of the OAR.In recent years,artificial intelligence(Al)has made great progress in the medical field.Machine learning and neural network have been widely applied in all aspects of BT,such as implantation of the applicator,image acquisition,segmentation of target area and OAR,reconstruction of the applicator,plan optimization,and treatment delivery,etc.In addition,BT significantly reduces the overall time,improves the homogeneity of operation,and enhances the accuracy of treatment.In this article,the application,development prospects,and challenges of Al in the BT of cervical cancer in recent years were reviewed,aiming to provide novel ideas for the application of Al in BT.

关 键 词：宫颈肿瘤 近距离治疗 人工智能 

分 类 号：R737.33[医药卫生—肿瘤]