流固耦合分析脉压差对颈内动脉狭窄处壁面剪切力的影响  

Fluid structure interaction analysis of the effect of pulse pressure difference on the wall shear stress at the stenosis of internal carotid artery

作　　者：李建伟[1] 纪盛章[1] 宋金玉[1] LI Jianwei;JI Shengzhang;SONG Jinyu(Tianjin Fourth Central Hospital,Tianjin 300140,China)

机构地区：[1]天津市第四中心医院,天津300140

出　　处：《介入放射学杂志》2023年第11期1131-1134,共4页Journal of Interventional Radiology

摘　　要：目的基于流固耦合(fluid structure interaction,FSI)的方式,分析不同脉压差对颈内动脉狭窄处壁面剪切力(wall shear stress,WSS)的影响。方法建模为颈内动脉轻度狭窄的CT血管造影(computed tomography angiography,CTA)图像,将模型导入FSI分析软件中。入口条件设定为A、B两组,A组8种入口条件:舒张压设定为80 mmHg,收缩压间隔10 mmHg由90~160 mmHg递增;B组8种入口条件:收缩压设定为120 mmHg,舒张压间隔10 mmHg由110~40 mmHg递减。获取两组数据后,分别测量颈内动脉狭窄处截面收缩期和舒张期的WSS数值和差值。结果两组WSS差值随着脉压差增大而增大,当压差为80 mmHg时,A组WSS差为92.821 Pa,B组WSS差为98.203 Pa,远高于正常压差(40 mmHg)的WSS差值52.041 Pa;B组脉压差越小,一个心动周期内的整体WSS越高,B组脉压差为10 mmHg时,收缩期和舒张期的WSS分别为220.384 Pa和204.744 Pa。结论颈内动脉狭窄处的脉压差增高,WSS的振荡幅度也会增大,易造成斑块破裂;当脉压差低且收缩压和舒张压同时偏高时,WSS整体也偏高,同样是斑块的易损因素,通过FSI分析脉压差对颈内动脉狭窄处的WSS数值,有助于临床预防和治疗。Objective Using fluid structure interaction(FSI)method to analyze the effect of different pulse pressure difference on the wall shear stress(WSS)at the stenosis of internal carotid artery.Methods CT angiography(CTA)images of mild stenosis of internal carotid artery were modeled,and the model data were input into the FSI analysis software.The entry conditions were set to two groups:A and B.The entry conditions for group A included 8 items:fixing the diastolic pressure at 80 mmHg,separately setting eight systolic pressures(from 90 mmHg to 160 mmHg with an increasing interval of 10 mmHg).The entry conditions for group A included 8 items:fixing the systolic pressure at 120 mmHg,separately setting eight diastolic pressures(from 110 mmHg to 40 mmHg with an decreasing interval of 10 mmHg).After obtaining the data of the two groups,the systolic and diastolic WSS and difference value(D-value)at the stenosis of internal carotid artery were separately measured.Results In both groups,the WSS D-value increased with the pulse pressure difference increasing.When the pressure difference was 80 mmHg,the WSS D-value in group A was 92.821 Pa,which in group B was 98.203 Pa.The WSS D-value of both groups was much higher than 52.041 Pa which was obtained when the pressure difference was at normal 40 mmHg.In group B,within a single cardiac cycle the smaller the pulse pressure difference was,the higher the overall WSS would be.In group B,when the pressure difference was 10 mmHg,the systolic WSS and diastolic WSS were 220.384 Pa and 204.744 Pa,respectively.Conclusion With the increasing of pulse pressure difference at the stenosis of internal carotid artery,the oscillation amplitude of WSS will also increase,which is prone to plaque rupture.When the pulse pressure difference is low and both systolic and diastolic blood pressure are high,the overall WSS will also be high,which is also a vulnerability factor of plaque.The FSI analysis about the effect of pulse pressure difference on WSS at the stenosis of internal carotid artery is helpful

关 键 词：脉压差 壁面剪切力 颈内动脉狭窄 流固耦合 

分 类 号：R743.3[医药卫生—神经病学与精神病学]