体重指数对非转移性前列腺癌患者预后的影响  

Effect of body mass index on prognosis of patients with non-metastatic prostate cancer

作　　者：黄维荪 许隽颖 晏芾 Huang Weisun;Xu Junying;Yan Fei(Department of Oncology,The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu,China;The Fourth Clinical Medical College,Nanjing Medical University,Nanjing 210009,Jiangsu,China)

机构地区：[1]南京医科大学附属无锡人民医院肿瘤科,江苏无锡214023 [2]南京医科大学第四临床医学院,江苏南京210009

出　　处：《中国男科学杂志》2023年第5期45-49,62,共6页Chinese Journal of Andrology

摘　　要：目的 评估诊断时体重指数(BMI)及诊断后体重变化对非转移性前列腺癌(PCa)患者生存状况的影响。方法 应用前瞻性研究方法。在患者就诊时和诊断后第2周年日期时测量其体重。在患者诊断后进行随访观察,分析患者诊断时基线体重和诊断后2年体重变化对患者预后指标的影响。结果 (1)本次调查的423例PCa患者中,体重正常137例,超重216例,肥胖70例。诊断2年后体重明显增加79例,轻微增加83例,体重不变147例,轻微减轻69人,明显减轻45例。(2)PCa患者3年无进展生存率(PFS)为70.69%,3年总体生存率(OS)为88.42%,3年PCa特异性生存率(CSS)为95.27%。(3)多因素Logistic回归显示:诊断时肥胖、诊断后体重明显减轻、诊断后体重明显增加是患者诊断后3年影响OS的危险因素(P<0.05);诊断时肥胖是PCa患者诊断后3年影响CSS的危险因素(P<0.05);诊断时肥胖、诊断后体重明显增加是患者在诊断后3年影响PFS的危险因素(P<0.05)。结论 确诊PCa后体重大量增加或大量降低都不利于患者预后。对PCa患者来说,在确诊后体重维持不变或改变轻微才是最利于预后的状态。Objective To evaluate the influence of body mass index(BMI)at diagnosis and weight change after diagnosis on the living conditions of patients with non-metastatic prostate cancer(PCa).Methods Prospective research method was used.The patient's weight was measured at the time of visit and the 2nd anniversary after diagnosis.Follow-up observation was carried out after diagnosis,and the influence of baseline weight at diagnosis and weight change at 2 years after diagnosis on prognosis index was analyzed.Results(1)Among the 423 PCa patients surveyed,137 were normal in weight,216 overweight and 70 obese.Two years after diagnosis,the weight increased significantly by 79 person,slightly increased by 83 person,remained unchanged by 147 person,slightly decreased by 69 person and significantly decreased by 45 person.(2)The 3-year progression-free survival(PFS)were 70.69%,3-year overall survival(OS)were,88.42%and 3-year cancer-specific survival(CSS)were 95.27%.(3)Multivariate Logistic regression showed that obesity at diagnosis,obvious weight loss and obvious weight increase after diagnosis were risk factors of 3 years OS after diagnosis(P<0.05).Obesity at diagnosis were risk factor for PCa patients in 3 years CSS after diagnosis(P<0.05).Obesity at diagnosis and weight gain after diagnosis were risk factors of PCa patients in 3 years PFS after diagnosis(P<0.05).Conclusion A large increase or decrease in body weight after PCa diagnosis is not conducive to the prognosis of patients.For PCa patients,it is the most favorable condition for prognosis that the weight remains unchanged or changes slightly after diagnosis.

关 键 词：人体质量指数 前列腺肿瘤 预后 

分 类 号：R737.25[医药卫生—肿瘤]