胆囊癌的靶向治疗研究进展  

Research advances in targeted therapy for gallbladder carcinoma

作　　者：杜丽文 刘建生[2] DU Liwen;LIU Jiansheng(Shanxi Medical University,Taiyuan,030001,China;Department of Hepatobiliary and Pancreatic Surgery,The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第一医院肝胆胰外科,太原030001

出　　处：《临床肝胆病杂志》2023年第12期2965-2969,共5页Journal of Clinical Hepatology

摘　　要：胆囊癌(GBC)是一种预后极差的恶性肿瘤,外科手术是目前最有效的治疗手段。但由于该疾病早期缺乏典型症状,患者在确诊时大多已进展至中晚期,失去根治性手术切除机会。在现有的辅助治疗方法中,靶向治疗是一种特异性较高且副作用较小的治疗手段,对多种癌症的预后产生了积极的效果。本文通过研究GBC靶向治疗的最新进展,对GBC靶向治疗的研究现状、潜在靶点及靶向药物研究进行综述,以期为GBC患者的临床治疗提供参考。Gallbladder carcinoma(GBC)is a type of malignant tumor with an extremely poor prognosis,and at present,surgical operation is the most effective treatment method for this disease.Unfortunately,due to a lack of typical symptoms in the early stage,most patients have progressed to the advanced stage at the time of confirmed diagnosis and lost the opportunity for radical surgery.Among the currently available adjuvant treatments,targeted therapy has higher specificity and fewer side effects and has improved the prognosis of a variety of malignancies.With reference to the latest research advances in targeted therapy for GBC,this article reviews the current research status,potential targets,and targeted medications of targeted therapy for GBC,in order to provide a reference for the clinical treatment of GBC patients.

关 键 词：胆囊肿瘤 信号传导 治疗学 

分 类 号：R735.8[医药卫生—肿瘤]