急性胰腺炎患者肠道菌群变化及益生菌的应用  

Changes in intestinal microbiota and application of probiotics in patients with acute pancreatitis

作　　者：吕彦青 李嘉杰 刘坤禹 郭汝华 季慧范[1] LYU Yanqing;LI Jiajie;LIU Kunyu;GUO Ruhua;JI Huifan(Department of Hepatobiliary and Pancreatic Medicine,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学白求恩第一医院肝胆胰内科,长春130021

出　　处：《临床肝胆病杂志》2023年第12期2970-2977,共8页Journal of Clinical Hepatology

基　　金：吉林市人口与健康发展研究(371170143428)。

摘　　要：肠道菌群是人体中最复杂和最重要的微生态系统,肠道菌群失调与急性胰腺炎的发生、发展密切相关,近年来靶向调控肠道微生态辅助治疗急性胰腺炎逐步被人们重视。本文详细叙述了急性胰腺炎患者肠道菌群变化情况及机制,总结了益生菌应用的研究现状,指出益生菌辅助治疗方案的研究方向,并提出了预测急性胰腺炎患者优势菌群的新方法,以期为急性胰腺炎的治疗带来新思路。Intestinal microbiota is the most complex and important microecosystem in the human body,and gut microbiota dysbiosis is closely associated with the development and progression of acute pancreatitis.Targeted regulation of intestinal microecology in assisting the treatment of acute pancreatitis has attracted more attention in recent years.This article describes the changes in intestinal microbiota and related mechanisms in patients with acute pancreatitis,summarizes the current research status of the use of probiotics,points out the research direction of probiotics as the adjuvant treatment regime,and proposes a new method for predicting the dominant flora in patients with acute pancreatitis,in order to bring new ideas for the treatment of acute pancreatitis.

关 键 词：胰腺炎 急性坏死性 胃肠道微生物组 鼠李糖乳杆菌 

分 类 号：R576[医药卫生—消化系统]