Accelerated Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydride via Inorganic Nano-initiators  

作　　者：Junliang Zhu Yunjie He Chenglong Ge Wenting Si Ziyuan Song Lichen Yin 

机构地区：[1]Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University,Suzhou,Jiangsu,215123 China

出　　处：《Chinese Journal of Chemistry》2023年第19期2476-2482,共7页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22101194 and 52273144);Science and Technology Department of Jiangsu Province(BK20210733).

摘　　要：While the accelerated polymerization of N-carboxyanhydrides (NCAs) has been utilized to synthesize versatile polypeptide materials in an efficient manner with minimized side reactions, the preparation of polypeptide-based inorganic/organic hybrid materials with the acceleration strategy remained largely unexplored. Herein, we report the accelerated ring-opening polymerization (ROP) of NCAs mediated by amine-modified inorganic nano-initiators, such as mesoporous silica nanoparticles (MSN-NH2), which is driven by the cooperative effect of the neighboring α-helical polypeptide chains in a dichloromethane (DCM)/water biphasic system. Well-defined nano-hybrids were prepared within 15 min from non-purified NCA monomers, through in situ purification and subsequent ultrafast polymerization process. NCAs can be rapidly initiated by amino groups of MSN uniformly dispersed at the interface of DCM and water, and subsequently formed the well-defined polypeptides within 15 min. The prepared inorganic/organic nano-hybrid with MSN as the core and polypeptide as the shell adopted spherical morphology and uniform size distribution due to the excellent controllability of ROP. Besides, this system is also suitable for a variety of NCAs and inorganic nano-initiators. This research allows efficient and rapid preparation of inorganic/organic nano-hybrids, and further promotes the extensive application of this material in the biomedical fields.

关 键 词：POLYPEPTIDE N-CARBOXYANHYDRIDE INORGANIC organic nano-hybrids Cooperative covalent polymerization Ring-opening polymerization Kinetics Synthetic methods 

分 类 号：O62[理学—有机化学]