Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization  

作　　者：Mengqin Hu Wei Cao Zhen Wang Yan Hao Ganxing Huang Yuqiao Zhou Song Qin Shaomin Fu Bo Liu 

机构地区：[1]Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu,Sichuan,610064 China

出　　处：《Chinese Journal of Chemistry》2023年第19期2502-2506,共5页中国化学（英文版）

基　　金：supported by NSFC(21925106,U19A2014);Si-chuan University(2020SCUNL204);Department of Science and Technology of Sichuan Province(2023NSFSC0105).

摘　　要：Photo-induced electron transfer (PET) of silyl enol ethers has been employed to synthesize several fused ring systems. However, the method has limited applicability due to its narrow substrate scope, low product yields, unsatisfactory stereo- and regioselectivity. Herein, we report a PET-triggered cascade reaction of silyl enolates that leads to the formation of angularly fused tricyclic scaffolds. The reaction exhibits broad substrate scope and excellent stereoselectivity. The regio- and stereoselectivity of this cascade reaction is elucidated via DFT calculation and conformational analysis.

关 键 词：CYCLIZATION RADICAL Tricyclic compounds PHOTOCATALYSIS ENOLS Fused-ring systems Domino reactions Regioselectivity 

分 类 号：O626.13[理学—有机化学]