当归活性成分生物合成与调控研究进展  

Advances in biosynthesis and regulation of active ingredients of Angelicae Sinensis Radix

作　　者：刘天乐 朱田田 张明惠 张菁 徐丽 康舒淇 晋玲 LIU Tian-le;ZHU Tian-tian;ZHANG Ming-hui;ZHANG Jing;XU Li;KANG Shu-qi;JIN Ling(School of Pharmacy,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province&MOE of PRC,Lanzhou 730000,China;Engineering Research Center for Evaluation,Protection and Utilization of Rare Traditional Chinese Medicine Resources,Lanzhou 730000,China;Gansu Pharmaceutical Industry Innovation Research Institute,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]西北中藏药省部共建协同创新中心,甘肃兰州730000 [3]甘肃省珍稀中药资源评价与保护利用工程研究中心,甘肃兰州730000 [4]陇药产业创新研究院,甘肃兰州730000

出　　处：《中草药》2023年第22期7545-7553,共9页Chinese Traditional and Herbal Drugs

基　　金：甘肃省高校青年博士基金资助项目(2023QB-094);西北中藏药省部共建协同创新中心开放基金资助项目(Xbzzy202207);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05);甘肃省科技计划项目(20JR5RA182);甘肃中医药大学科学研究与创新基金项目(2021KCZD-4)。

摘　　要：当归为伞形科植物当归Angelica sinensis的干燥根,具有补血活血、调经止痛、润肠通便的功效。酚酸类、黄酮类、香豆素类、多糖类及苯酞类等活性成分是当归发挥药效的物质基础。近年来,已有大量研究对当归中部分成分的生物合成途径进行解析,并对途径中关键酶基因及转录因子进行克隆与表达分析。当归活性成分合成和积累的调控因素主要包括早期抽薹和生境条件,可以影响合成途径中的基因表达,进而改变活性成分的含量。通过对当归中已被解析的活性成分生物合成途径及这些成分的调控因素进行综述,为当归的品质提升、品种改良和精准栽培提供理论基础。Danggui(Angelicae Sinensis Radix)is the dried root of Angelica sinensis,a plant of the Umbelliferae family,which has the effect of tonifying blood,regulating menstruation,relieving pain and laxative.Important active ingredients such as phenolic acids,flavonoids,coumarins,polysaccharides and phthalides are the material basis for the medicinal effects of Angelicae Sinensis Radix.In recent years,a large number of studies have been conducted to analyze the biosynthetic pathways of some components in Angelicae Sinensis Radix,and to clone and analyze the expression of key enzyme genes and transcription factors in the pathways.Regulatory factors for the synthesis and accumulation of active components of Angelicae Sinensis Radix,mainly including early bolting and habitat conditions,can affect the expression of genes in the synthesis pathway,which changes the content of active components.By synthesizing the biosynthetic pathways of the resolved active components and the regulatory factors of these components in Angelicae Sinensis Radix,we can provide a theoretical basis for the quality enhancement,variety improvement and precision cultivation of Angelicae Sinensis Radix.

关 键 词：当归 生物合成途径 调控因素 阿魏酸 绿原酸 

分 类 号：R282[医药卫生—中药学]