自身炎症性疾病相关的中性粒细胞性皮肤病发病机制研究进展  

Research Progress in Pathogenesis of Neutrophilic Skin Diseases Related to Autoimmune Inflammatory Diseases

作　　者：张海妮 王宝玺 ZHANG Haini;WANG Baoxi(Department of Dermatology,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院皮肤科,北京100144

出　　处：《医学综述》2023年第22期4801-4807,4814,共8页Medical Recapitulate

基　　金：国家自然科学基金(82073471)。

摘　　要：中性粒细胞性皮肤病(NDs)是一组中性粒细胞在皮肤中异常蓄积引起的疾病,其发病机制尚不清楚。自身炎症性疾病是一组固有免疫系统功能障碍引起的罕见病,部分自身炎症性疾病常表现出中性粒细胞性皮疹,其在临床表现、发病机制、治疗等方面与NDs有一定相似性。自身炎症性疾病相关白细胞介素-1通路异常等在NDs中发挥重要作用。另外,部分NDs发病与地中海发热、脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白1等自身炎症性疾病相关的基因变异相关,因此NDs可能是一种自身炎症性疾病。Neutrophilic skin diseases(NDs)are a group of diseases caused by the abnormal accumulation of neutrophils in the skin,and the pathogenesis is still unclear.Autoinflammatory diseases are a rare group of diseases caused by innate immune system dysfunction.Some autoimmune diseases often exhibit neutrophil rash,which has certain similarities with NDs in clinical manifestations,pathogenesis,treatment,and other aspects.Abnormal interleukin-1 pathways related to autoimmune diseases play an important role in NDs.In addition,some NDs are associated with genetic variations related to autoimmune diseases such as Mediterranean fever and proline-serine-threonine phosphatase interacting protein 1,suggesting that NDs may be an autoimmune disease.

关 键 词：中性粒细胞性皮肤病 自身炎症性疾病 基因变异 白细胞介素-1 

分 类 号：R758.69[医药卫生—皮肤病学与性病学]