复发性口腔溃疡相关基因多态性的研究进展  

Research Progress of Gene Polymorphism Related to Recurrent Aphthous Ulcer

作　　者：王春磊 李子涵 张萍 陈傲 李文艺 刘雪 WANG Chunlei;LI Zihan;ZHANG Ping;CHEN Ao;LI Wenyi;LIU Xue(School of Medical Stomatology,Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院口腔医学院,山东济宁272000

出　　处：《医学综述》2023年第22期4871-4875,共5页Medical Recapitulate

基　　金：济宁市重点研发计划项目(2021YXNS032);山东省大学生创新创业训练计划项目(S202210443019);济宁医学院大学生创新创业训练计划项目(cx2021026)。

摘　　要：复发性口腔溃疡(RAU)发病机制复杂,目前其具体致病机制尚不明确,可能与遗传因素、免疫因素、微生物因素等有关,其发病具有周期性、复发性、自限性等特点,在人群中发病率高,严重影响患者的日常生活。大量研究指出,免疫应答机制中E-选择素、5-羟色胺转运体、甘露糖结合凝集素、白细胞介素、γ干扰素、核因子κB等相关基因及其位点的多态性与RAU的发生发展具有一定关联。未来深入探究基因及其位点多态性在RAU发病机制中的作用,可为RAU的治疗提供新思路。The pathogenesis of recurrent aphthous ulcer(RAU)is complex,and the specific pathogenesis of RAU is still unclear.It may be related to genetic factors,immune factors,microbial factors etc.RAU is characterized with periodic,recurrent,and self-limited onset,with high incidence in the population,which seriously affects the daily life of the patients.A large number of studies have shown that the genes and loci polymorphisms of E-selectin,serotonin transporter,mannose-binding lectin,interleukin,interferon-γ,nuclear factor-κB in the immune response mechanism are associated with the occurrence and development of RAU.In the future,a deep exploration of the role of the genes and their loci polymorphisms in the pathogenesis of RAU can provide new ideas for the treatment of RAU.

关 键 词：复发性口腔溃疡 基因多态性 细胞因子 受体 病因 

分 类 号：R781.5[医药卫生—口腔医学]