丹红注射液治疗皮层下动脉粥样硬化型脑病的临床效果研究  

Study on clinical effect of Danhong injection on subcortical atherosclerotic encephalopathy

作　　者：杜雨 徐昕宇 DU Yu;XU Xin-yu(Department of Neurology,Anshan Hospital of Traditional Chinese Medicine,Anshan 114004,China)

机构地区：[1]辽宁省鞍山市中医院神经内科,114004

出　　处：《中国实用医药》2023年第22期94-97,共4页China Practical Medicine

摘　　要：目的探讨丹红注射液治疗皮层下动脉粥样硬化型脑病的临床效果。方法选择90例皮层下动脉粥样硬化性脑病患者为研究对象,按照随机数字表法分为对照组和观察组,各45例。两组患者均进行神经内科常规干预,对照组使用胞二磷胆碱联合依达拉奉治疗,观察组在对照组基础上联合丹红注射液治疗。比较两组治疗后血液流变学指标,治疗前后欧洲脑卒中量表(ESS)评分和语言能力评分,临床效果,总住院时间。结果治疗后,观察组全血浆粘度为(1.4±0.2)mPa·s低于对照组的(2.9±0.6)mPa·s,红细胞电泳时间(15.2±0.7)s短于对照组的(18.1±0.3)s,差异具有统计学意义(P<0.05)。治疗后,两组ESS评分和语言能力评分均高于本组治疗前,观察组ESS评分和语言能力评分均高于对照组,差异具有统计学意义(P<0.05)。观察组总有效率97.8%高于对照组的77.8%,差异具有统计学意义(P<0.05)。观察组总住院时间(10.5±2.2)d显著短于对照组的(13.1±3.5)d,差异具有统计学意义(t=4.219,P=0.000<0.05)。结论丹红注射液治疗皮层下动脉粥样硬化性脑病能有效降低患者血液粘度,改善患者神经功能,确保临床治疗效果,缩短住院时间。Objective To discuss the clinical effect of Danhong injection on subcortical atherosclerotic encephalopathy.Methods A total of 90 patients with subcortical atherosclerotic encephalopathy were divided into a control group and an observation group according to the random numerical table,with 45 cases in each group.Patients in both groups received routine neurological intervention.On this basis,the control group was treated with citicoline and edaravone,and the observation group was treated with Danhong injection on the basis of the control group.Both groups were compared in terms of hemorheology index,European Stroke Scale(ESS)score and language ability score before and after treatment,clinical effect and total length of hospital stay.Results After treatment,the plasma viscosity of(1.4±0.2)mPa·s in the observation group was shorter than that of(2.9±0.6)mPa·s in the control group,and the erythrocyte electrophoresis time of(15.2±0.7)s was higher than that of(18.1±0.3)s in the control group.The differences were statistically significant(P<0.05).After treatment,ESS score and language ability score in both groups were higher than those before treatment in this group,and ESS score and language ability score in the observation group were higher than those in the control group.The differences were statistically significant(P<0.05).The total effective rate of 97.8%in the observation group was higher than that of 77.8%in the control group,and the difference was statistically significant(P<0.05).The total hospitalization time of(10.5±2.2)d in the observation group was significantly shorter than that of(13.1±3.5)d in the control group,and the difference was statistically significant(t=4.219,P=0.000<0.05).Conclusion Danhong injection in the treatment of subcortical atherosclerotic encephalopathy can effectively reduce the plasma viscosity of patients,improve the neurological function of patients,ensure clinical therapeutic effect and shorten hospital stay.

关 键 词：丹红注射液 皮层下动脉粥样硬化型脑病 血液粘度 神经功能 语言功能 

分 类 号：R743.1[医药卫生—神经病学与精神病学]