早期宫颈癌术后不同治疗方法的临床效果分析  

Analysis of therapeutic effect of different treatment Methods after operation of early cervical cancer

作　　者：曾美男[1] Zeng Meinan(Department of Gynecology,Yuexiu Hospital,Guangdong Maternal and Child Health Hospital,Guangzhou 510010,China)

机构地区：[1]广东省妇幼保健院越秀院区妇科,广东广州510010

出　　处：《实用妇科内分泌电子杂志》2023年第24期28-30,85,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析早期宫颈癌术后不同治疗方法的临床效果。方法选取60例宫颈癌术后患者,按照患者意愿分为对照组与试验组,每组30例。对照组予以术后观察模式,试验组予以化疗治疗。比较两组不良反应发生情况、血清T淋巴细胞亚群值的变化情况。结果60例患者5年总生存期(OS)为100%,5年无进展生存期(PFS)为83.33%。试验组较对照组可延长患者5年PFS发生率高(P<0.05)。术后残端复发为最常见部位。试验组的严重急性胃肠道反应发生情况高于对照组(P<0.05)。化疗后辅助/诱导T细胞绝对计数(CD3^(+)CD4^(+))明显低于化疗前(P<0.05)。结论对于至少有2个中危因素的早期宫颈癌患者术后治疗,可积极应用化疗方法,能延长患者无进展生存期,使得辅助/诱导T细胞绝对计数下降。Objective To analyze the therapeutic effect of different treatment Methods after operation of early cervical cancer.Methods 60 patients with cervical cancer were selected and divided into control group and experimental group according to the patients'wishes,with 30 cases in each group.The control group was treated with postoperative observation mode,and the experimental group was treated with chemotherapy.The occurrence of adverse reactions and the changes of serum T lymphocyte subsets were compared between the two groups.Results The 5-year overall survival(OS)of 60 patients was 100%,and 5-year progression-free survival(PFS)was 83.33%.The incidence of 5-year PFS in experimental group was higher than that in control group(P<0.05).Stump recurrence was the most common site after operation.The occurrence of severe acute gastrointestinal reactions in experimental group was higher than that in control group(P<0.05).The absolute count of adjuvant/induced T cells(CD3^(+)CD4^(+))after chemotherapy was significantly lower than that before chemotherapy(P<0.05).Conclusion for at least two risk factors in patients with early cervical cancer treatment,postoperative chemotherapy can be a positive way,patients can prolong progression-free surial,makes the auxiliary/induction of T cell count down absolutely.

关 键 词：早期宫颈癌 化疗 血清T淋巴细胞亚群 

分 类 号：R737.33[医药卫生—肿瘤]