脑外伤后颅内感染患者血清S100、脑脊液WBC与神经行为的相关性  

Correlation between Serum S100,Cerebrospinal Fluid WBC and Neurobehavior in Patients with Intracranial Infection after Traumatic Brain Injury

作　　者：铁江辉 马琳 TIE Jiang-hui;MA Lin(Neurosurgery Department,Gongyi City People's Hospital,Gongyi 451200,Henan Province,China)

机构地区：[1]巩义市人民医院神经外科,河南巩义451200

出　　处：《罕少疾病杂志》2023年第12期27-29,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨脑外伤后颅内感染患者血清S100、脑脊液白细胞计数(WBC)与神经行为的相关性。方法2015年4月到2020年6月选择在本院进行诊治的脑外伤患者84例作为研究对象,其中颅内感染患者20例作为感染组,非颅内感染患者作为对照组,检测血清S100值与进行脑脊液WBC计数,评定患者的神经行为并进行相关性分析。结果感染组血清S100、血清WBC计数高于对照组,具有统计学意义(P<0.05);而性别、年龄、创伤部位、原因以及严重程度对比均无差异(P>0.05)。染组的神经行为评分的各项指标评分均明显低于对照组,两组对比差异明显(P<0.05),感染组中神经行为障碍的发生率为55.00%,高于对照组的12.50%(P<0.05)。在感染组中,Spearman秩相关分析显示神经行为评分各项指标与血清S100、脑脊液WBC都存在负相关。logistic回归分析显示:血清S100、脑脊液WBC是间接导致神经行为障碍的影响因素(P=0.018、0.005,P<0.05)。结论脑外伤后颅内感染患者血清S100、脑脊液WBC高表达与神经行为障碍存在相关性,血清S100、脑脊液WBC是间接导致神经行为障碍的影响因素。Objective To investigate the correlation between serum S100,cerebrospinal fluid white blood cell count(WBC)and neurobehavior in patients with intracranial infection after traumatic brain injury.Methods From April 2015 to June 2020,84 cases of patients with brain trauma who were diagnosed and treated in our hospital were selected as the research objects.There were 20 patients with intracranial infection were used as the infection group,and patients without intracranial infection were used as the control group.The serum S100 wand the WBC count of cerebrospinal fluid were detected,and were to evaluate the neurobehavior of the patient and analysis the correlation.Results The serum S100 and WBC counts in the infection group were higher than those in the control group,with statistical significance(P<0.05);However,there were no differences in gender,age,location of trauma,cause,and severity(P>0.05).The neurological behavioral scores of the infection group were significantly lower than those of the control group,with significant differences between the two groups(P<0.05).The incidence of neurological behavioral disorders in the infection group was 55.00%,higher than the control group's 12.50%(P<0.05).In the infection group,Spearman rank correlation analysis showed a negative correlation between various indicators of neurobehavioral score and serum S100 and cerebrospinal fluid WBC.Logistic regression analysis showed that serum S100 and cerebrospinal fluid WBC were indirect influencing factors for neurobehavioral disorders(P=0.018,0.005,P<0.05).Conclusion The high expression of serum S100 and CEREBROspinal fluid WBC in patients with intracranial infection after traumatic brain injury is correlated with neurobehavioral disorders,and serum S100 and CEREBROspinal fluid WBC are the influencing factors that indirectly lead to neurobehavioral disorders.

关 键 词：脑外伤 颅内感染 S-100蛋白 脑脊液 神经行为障碍 

分 类 号：R749.11[医药卫生—神经病学与精神病学]