右美托咪定对行肝癌切除术患者血流动力学及苏醒质量的影响  

Effect of Dexmedetomidine on Hemodynamics and Quality of Awakening in Patients Undergoing Hepatocellular Carcinoma Resection

作　　者：曾垂应[1] 赖玥[1] ZENG Chui-ying;LAI Yue(The Second Hospital of Longyan City,Longyan 364100,Fujian Province,China)

机构地区：[1]福建省龙岩市第二医院,福建龙岩364100

出　　处：《罕少疾病杂志》2023年第12期75-76,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨右美托咪定对行肝癌切除术患者动脉压(MAP)、中心静脉压(CVP)、心率、自主呼吸时间、睁眼时间、握拳时间及苏醒质量的影响。方法将2019年1月到2020年12月来我院就诊的84例肝癌患者列为研究对象,其中有4例患者因不符合入选标准而被剔除,最终共有80例患者纳入本次研究。随机分组,各40例。两组均进行肝癌切除术,观察组硬膜外注入0.5μg/kg右美托咪定,对照组注入生理盐水,两组后续麻醉方案相同。比较两组血流动力学、苏醒时间与苏醒期不良反应。结果观察组T1-T3时MAP、心率均出现波动,但观察组均低于对照组(P<0.05);观察组自主呼吸时间(16.51±2.38)min、睁眼时间(17.29±2.74)min、握拳时间(16.49±2.58)min均长于对照组(13.24±2.05)min、(14.42±2.65)min、(13.65±2.33)min(P<0.05);观察组不良反应发生率为5.00%(2/40)低于对照组的30.00%(12/40)(P<0.05)。结论右美托咪定用于肝癌切除术中可维持MAP、CVP、心率稳定,且苏醒期不良反应发生率低,利于提升麻醉安全性,值得广泛应用。Objective To investigate the effects of dexmedetomidine on arterial pressure(MAP),central venous pressure(CVP),heart rate,spontaneous respiration time,eye opening time,fist clenching time and quality of awakening of patients undergoing hepatic cancer resection.Methods Eightyfour patients with hepatocellular carcinoma who visited our hospital from January 2019 to December 2020 were included in the study,of which four patients were excluded because they did not meet the inclusion criteria,and finally a total of 80 patients were included in this study.They were randomly divided into 40 cases each.Hepatoma resection was performed in both groups.The observation group was given an epidural injection of 0.5μg/kg dexmedetomidine,while the control group was given normal saline.The follow-up anesthesia regimen was the same in both groups.Hemodynamics,recovery time and adverse reactions during recovery were compared between the two groups.Results MAP and heart rate fluctuated at T1-T3 in the observation group,but they were lower in the observation group than in the control group(P<0.05);the time of voluntary respiration in the observation group(16.51±2.38)min,the time of opening the eyes(17.29±2.74)min,and the time of clenching the fists(16.49±2.58)min were longer than those in the control group(13.24±2.05)min,(14.42±2.65)min,(13.65±2.33)min(P<0.05);the incidence rate of adverse reactions in the observation group was 5.00%(2/40)lower than that in the control group,which was 30.00%(12/40)(P<0.05).Conclusion Dexmedetomidine can maintain stable MAP,CVP and heart rate during hepatic cancer resection and has a low incidence of adverse reactions during the awakening period,which is conducive to improving the safety of anaesthesia and deserves to be widely used.

关 键 词：肝癌切除术 右美托咪定 血流动力学 苏醒质量 

分 类 号：R575[医药卫生—消化系统]