非小细胞肺癌细胞学标本上清液驱动基因规范化检测指南(2023年版)  

Guideline for standardized driver genes detection of cytology specimen supernatants in non-small cell lung cancer(version 2023)

作　　者：中华医学会病理学分会工作组 北京病理学会工作组 刘东戈 石远凯 梁智勇 王征 应建明 周晓燕 何淑蓉 何磊 Working Group of Chinese Society of Pathology;Working Group of Beijing Society of Pathology;Liu Dongge;Shi Yuankai;Liang Zhiyong(不详;Department of Pathology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Science,Bejing,100730,China;Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs,Beijing 100021,China;Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China)

机构地区：[1]不详 [2]国家老年医学中心、中国医学科学院老年医学研究院、北京医院病理科,北京100730 [3]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院内科、抗肿瘤分子靶向药物临床研究北京市重点实验室,北京100021 [4]中国医学科学院、北京协和医学院、北京协和医院病理科,北京100730 [5]国家老年医学中心中国医学科学院老年医学研究院北京医院病理科 [6]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院病理科 [7]复旦大学附属肿瘤医院病理科

出　　处：《中国肿瘤临床与康复》2023年第7期397-405,共9页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：中央高水平医院临床科研业务费资助(BJ-2022-077)。

摘　　要：非小细胞肺癌(NSCLC)靶向治疗药物的选择依据驱动基因检测结果,细胞学标本是NSCLC驱动基因检测的重要标本类型,而建立在病理评估基础上的细胞学标本上清液游离核酸检测,其准确性与肿瘤组织标本接近,但实验室内及实验室间检测标本的制备方法、检测方法和质量控制措施等均需要进一步统一和规范,故此制定NSCLC细胞学标本上清液驱动基因规范化检测指南,并在驱动基因检测的适用范围、标本类型、细胞学标本上清液制备流程和检测方法推荐等方面达成共识,规范并推动细胞学标本上清液驱动基因检测工作,完善NSCLC驱动基因检测临床实践.Targeted therapeutic strategy options are depended on the driver genes detection,and cytology is one of important specimen for genomic profiling in non-small cell lung cancer(NSCLC).Accumulating evidence suggests,based on pathological evaluation,that the accuracy of detecting cellfree nucleic acid from cytology specimen supernatants is similar to that of tumor tissue specimen.However,preparation of specimen,method of detection and quality control,etc.are inconsistent and need to be further unified and standardized.Therefore,guideline for standardized driver genes detection of cytology specimen supernatants in NSCLC is developed,and consensuses including clinical applications,specimen types,preparation procedures for cytology specimen supernatants,detection method choices,etc.have been reached in driver genes detecting for NSCLC.The purpose of this guideline is to standardize and promote driver genes detecting in cytology specimen supernatants and improve the clinical practice in genotyping for NSCLC.

关 键 词：非小细胞肺癌 指南 细胞学标本上清液 驱动基因 液体活检 

分 类 号：R734.2[医药卫生—肿瘤]