Photobiomodulation therapy assisted orthodontic tooth movement:potential implications,challenges,and new perspectives  

作　　者：Jiawen YONG Sabine GROGER Julia VON BREMEN Marcia MARTINS MARQUES Andreas BRAUN Xiaoyan CHEN Sabine RUF Qianming CHEN 

机构地区：[1]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou,310000,China [2]Department of Orthodontics,Faculty of Medicine,Justus Liebig University Giessen,Giessen,35392,Germany [3]School of Dentistry,University of Sao Paulo,Sao Paulo,05508000,Brazil [4]Department of Operative Dentistry,Periodontology and Preventive Dentistry,RWTH Aachen University,Aachen,52074,Germany

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第11期957-973,共17页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China (Nos.81991500 and 81991502).

摘　　要：Over the past decade,dramatic progress has been made in dental research areas involving laser therapy.The photobiomodulatory effect of laser light regulates the behavior of periodontal tissues and promotes damaged tissues to heal faster.Additionally,photobiomodulation therapy(PBMT),a non-invasive treatment,when applied in orthodontics,contributes to alleviating pain and reducing inflammation induced by orthodontic forces,along with improving tissue healing processes.Moreover,PBMT is attracting more attention as a possible approach to prevent the incidence of orthodontically induced inflammatory root resorption(OIIRR)during orthodontic treatment(OT)due to its capacity to modulate inflammatory,apoptotic,and anti-antioxidant responses.However,a systematic review revealed that PBMT has only a moderate grade of evidence-based effectiveness during orthodontic tooth movement(OTM)in relation to OIIRR,casting doubt on its beneficial effects.In PBMT-assisted orthodontics,delivering sufficient energy to the tooth root to achieve optimal stimulation is challenging due to the exponential attenuation of light penetration in periodontal tissues.The penetration of light to the root surface is another crucial unknown factor.Both the penetration depth and distribution of light in periodontal tissues are unknown.Thus,advanced approaches specific to orthodontic application of PBMT need to be established to overcome these limitations.This review explores possibilities for improving the application and effectiveness of PBMT during OTM.The aim was to investigate the current evidence related to the underlying mechanisms of action of PBMT on various periodontal tissues and cells,with a special focus on immunomodulatory effects during OTM.

关 键 词：Photobiomodulation therapy Low-level laser therapy(LLLT) Low-intensity laser therapy(LILT) Orthodontic tooth movement ORTHODONTICS Immunorthodontics 

分 类 号：R730.51[医药卫生—肿瘤]