创伤性脑损伤后继发性1型发作性睡病1例  

Secondary type 1 narcolepsy after traumatic brain injury: a case report

作　　者：王芬[1] 袁于青 谢亮[1] Wang Fen;Yuan Yuqing;Xie Liang(Department of Neurology,the Second Affiliated Hospital of Nanchang University,Jiangxi Key Laboratory of Neurological Tumors and Cerebrovascular Diseases,Jiangxi Health Commission Key Laboratory of Neurological Medicine,Institute of Neuroscience,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院神经内科、江西省神经系统肿瘤及脑血管疾病重点实验室、江西省神经医学重点实验室、南昌大学神经科学研究所,南昌330006

出　　处：《中华神经科杂志》2023年第12期1424-1427,共4页Chinese Journal of Neurology

摘　　要：1型发作性睡病是一种罕见的中枢神经系统疾病,一般认为是环境因素和遗传因素相互作用的结果。创伤性脑损伤(TBI)是继发性发作性睡病最常见的病因之一。目前国内外关于TBI后发作性睡病的报道非常少见。本例是国内报道的首例HLA-DQB1*06:02阳性的TBI后1型发作性睡病患者。现将我院收治的这例患者的临床资料进行回顾性分析,旨在提高临床医师对该疾病诊断及其发病机制的认识。Type 1 narcolepsy is a rare central nervous system disorder that is believed to result from the interaction of environmental and genetic factors.Traumatic brain injury(TBI)is one of the most common causes of secondary narcolepsy.Currently,there are very few reports on post-TBI narcolepsy,and this patient is the first reported case of HLA-DQB1*06:02-positive type 1 narcolepsy following TBI in China.The clinical data of this patient are retrospectively analyzed to improve the understanding of the diagnosis and pathogenesis of the disease among clinicians.

关 键 词：脑损伤 弥漫性轴索损伤 发作性睡病 HLA-DQB1*06:02 

分 类 号：R740[医药卫生—神经病学与精神病学] R651.15[医药卫生—临床医学]