葡萄糖代谢在老年认知功能障碍中的研究进展  

Research progression on glucose metabolism in cognitive dysfunction in the elderly

作　　者：李林[1] 王蕾[1] Li Lin;Wang Lei(Department of General Medicine,the Third Hospital of Shanri Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanri Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院)综合医疗科,太原030032

出　　处：《中华老年医学杂志》2023年第12期1500-1504,共5页Chinese Journal of Geriatrics

基　　金：山西省自然科学研究面上项目(202203021211068)。

摘　　要：随着年龄的增长,葡萄糖代谢发生变化。有研究显示,葡萄糖代谢与老年认知功能存在着联系,其在老年认知功能障碍中的可能机制有氧化应激、葡萄糖利用下降、糖酵解受损、胰岛素抵抗、慢性炎症、线粒体功能障碍等,有效的干预不仅局限于药物治疗,还包括饮食方式的改变。本文围绕葡萄糖代谢在老年认知功能障碍中的研究进展进行综述,以期从更早期进行干预,减少或延缓老年认知功能障碍的发生。Glucose metabolism changes with age.Some studies have shown that there is a link between glucose metabolism and cognitive function in the elderly,and possible underlying mechanisms in cognitive dysfunction in the elderly include oxidative stress,decreased glucose utilization,impaired glycolysis,insulin resistance,chronic inflammation,and mitochondrial dysfunction.Effective interventions are not limited to pharmacotherapy but also include changes in dietary patterns.This article reviews the progress in research on glucose metabolism in cognitive dysfunction in older adults,with the aim of promoting intervention at earlier stages to reduce or delay the onset of cognitive dysfunction inelderly people.

关 键 词：葡萄糖代谢 认知功能 

分 类 号：R749.1[医药卫生—神经病学与精神病学]