DYRK2在肿瘤发生发展及预后中的研究进展  

Research progress of DYRK2 in tumor occurrence,development,and prognosis

作　　者：张杰 蒋依憬 吴雅珣 Zhang Jie;Jiang Yijing;Wu Yaxun(Department of Oncology,Nantong Tumor Hospital/Tumor Hospital Affiliated to Nantong University;Department of Pathophysiology,Medical School,Nantong University;Department of Pathology,Nantong Tumor Hospital/Tumor Hospital Affiliated to Nantong University)

机构地区：[1]南通市肿瘤医院/南通大学附属肿瘤医院肿瘤内科,南通226361 [2]南通大学医学院病理生理学教研室,南通226001 [3]南通市肿瘤医院/南通大学附属肿瘤医院病理科,南通226361

出　　处：《重庆医科大学学报》2023年第11期1308-1313,共6页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:82000202);南通市科技局青年基金资助项目(编号:JCZ2022072);南通市卫健委青年基金资助项目(编号:QA2021033)。

摘　　要：双特异性酪氨酸磷酸化调节激酶2(dual-specificity tyrosine-phosphorylation-regulated kinase 2,DYRK2)属于DYRK家族,是真核生物中一种进化保守的酶。DYRK2在不同组织及肿瘤中的表达具有较大差异。既往关于DYRK2在肿瘤中的作用报道表明DYRK2通过延长G1期、促进细胞凋亡及抑制上皮-间充质转化来延缓肿瘤生长。近年来研究发现DYRK2亦可通过促进细胞有丝分裂、抗肿瘤凋亡、促进细胞侵袭、迁移及增强耐药而发挥促癌作用。本文就DYRK2的结构、功能及其在肿瘤发生发展中的作用及预后价值进行综述。Dual-specificity tyrosine-phosphorylation-regulated kinase 2(DYRK2)belongs to the DYRK family and is an evolution⁃arily conserved enzyme in eukaryotes.The expression of DYRK2 varies greatly in different tissues and tumors.Previous reports on the role of DYRK2 in tumors have shown that it can delay tumor growth by prolonging G1 phase,promoting apoptosis,and inhibiting epithelial-mesenchymal transition.Recent studies have found that DYRK2 can also play a cancer-promoting role by enhancing cell mitosis,tumor apoptosis resistance,cell invasion and migration,and drug resistance.Here we present a review of the structure and function of DYRK2 as well as its roles in tumor occurrence,development,and prognosis.

关 键 词：双特异性酪氨酸磷酸化调节激酶2 肿瘤 文献综述 

分 类 号：R730.23[医药卫生—肿瘤]