终末期肝病合并真菌感染诊断现状与未来  

Current status and future of fungal infection diagnosis in end-stage of liver diseases

作　　者：黄蓝月 刘芸辉 程秋瑜 钮雨鑫 刘婷婷 张梦 朱琳[1] 宁琴[1] 陈韬[1] HUANG Lan-yue;LIU Yun-hui;CHENG Qiu-yu;CHEN Tao(Department of Infectious Diseases,Tongji Hospital,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease,Huazhong University of Science and Technology,Wuhan Hubei,430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,人畜共患传染病重症诊治全国重点实验室,湖北武汉430030

出　　处：《中西医结合肝病杂志》2023年第12期1057-1060,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家重点研发计划(No.2021YFC2600200);湖北省自然科学基金(No.2021CFB353);。

摘　　要：终末期肝病(ESLD)是各种慢性肝脏损害所致的肝病晚期阶段,主要特征为肝脏功能不能满足人体的生理需求。真菌感染是ESLD最常见的并发症,是患者短期死亡的高危风险因素。ESLD合并真菌感染的临床表现常缺乏特异性,容易被医务人员忽视。真菌培养以及真菌特异性抗原检测/血清曲霉特异性抗原试验等真菌检测已应用于临床实践,但是由于ESLD疾病的特殊性,其诊断价值尚存在一定的局限性。该文就ESLD合并真菌感染的诊断现状与挑战进行综述。End stage of liver diseases(ESLD)is the advanced stage of liver disease caused by various chronic liver damage,which is mainly characterized by liver function that cannot meet the physiological needs of the human body.Fungal infection is the most common complication of ESLD and is a high-risk factor for short-term mortality.The clinical manifestations of ESLD complicated with fungal infection are often non-specific and easily ignored by medical staff.Although there are fungal detection related tests applied to clinical practice,due to the particularity of ESLD disease,its diagnostic value still has certain limitations.This article provides a comprehensive review of the current diagnosis status and challenges of ESLD-associated fungal infections.

关 键 词：终末期肝病 真菌感染 诊断 现状 进展 

分 类 号：R575[医药卫生—消化系统]