色甘萘甲那敏鼻喷雾剂联合鼻用激素治疗儿童持续性变应性鼻炎的疗效及对睡眠质量的影响  

Effects of Serranyl and Methylamine Nasal Spray Combined with Nasal Hormone on Children with Persistent Allergic Rhinitis and Sleep Quality

作　　者：吴志扬 林鹏翔 黄心原 WU Zhiyang;LIN Pengxiang;HUANG Xinyuan(Department of Critical Care Medicine,Children′s Hospital,Quanzhou Maternal and Child Health Hospital,Quanzhou,Fujian Province,Quanzhou 362000,China;Department of Pediatrics,Nan′an Maternal and Child Health Hospital,Fujian Province,Nan′an 362700,China)

机构地区：[1]福建省泉州市妇幼保健院儿童医院重症医学科,泉州362000 [2]福建省南安市妇幼保健院儿科,南安362700

出　　处：《世界睡眠医学杂志》2023年第9期2095-2097,共3页World Journal of Sleep Medicine

摘　　要：目的:探讨色甘萘甲那敏鼻喷雾剂联合鼻用激素治疗儿童持续性变应性鼻炎的疗效及对睡眠质量的影响。方法:选取2022年2月至2022年10月福建省泉州市妇幼保健院儿童医院重症医学科收治的持续性变应性鼻炎患儿97例作为研究对象,按照随机数字表法分为观察组(n=51)和对照组(n=46)。观察组采用色甘萘甲那敏鼻喷雾剂联合鼻用激素治疗,对照组采用鼻用激素治疗,治疗10 d。比较2组临床疗效,比较2组治疗前后睡眠质量[采用匹兹堡睡眠质量指数量表(PSQI)评分];比较2组治疗后不良反应发生率。结果:观察组总有效率94.11%(48/51),对照组总有效率76.08%(35/46),观察组总有效率高于对照组(P<0.05)。2组治疗后,对照组PSQI睡眠时间、睡眠效率、入睡时间、睡眠质量、催眠药物、睡眠障碍、日间功能障碍评分高于观察组(P<0.05)。2组治疗后,胸闷、皮疹、皮肤肿胀、鼻出血、鼻刺激、鼻腔干燥及头痛不良反应比较差异无统计学意义(P>0.05)。结论:采用色甘萘甲那敏鼻喷雾剂联合鼻用激素治疗儿童持续性变应性鼻炎能显著提高疗效,改善睡眠质量,同时安全性较高,具有临床推广价值。Objective:To investigate the therapeutic effect of Semene Glycyrrhizinate Methylamine Nasal Spray combined with nasal hormone on children with persistent allergic rhinitis and its influence on sleep quality.Methods:A total of 97 children with persistent allergic rhinitis admitted to the Intensive Care Department of Children′s Hospital of Quanzhou Maternal and Child Health Hospital in Fujian Province from February 2022 to October 2022 were selected as the study subjects.They were randomly divided into an observation group(n=51)and a control group(n=46)using a random number table method.The observation group was treated with secranine and methylamine nasal spray combined with nasal hormone,and the control group was treated with nasal hormone for 10 days.Compare the clinical efficacy of two groups and compare their sleep quality before and after treatment(using the Pittsburgh Sleep Quality Index(PSQI)score).Compare the incidence of adverse reactions between the two groups after treatment.Results:The total effective rate of the observation group was 94.11%(48/51),while that of the control group was 76.08%(35/46).The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment in both groups,the PSQI sleep time,sleep efficiency,sleep onset time,sleep quality,hypnotic drugs,sleep disorders,and daytime dysfunction scores in the control group were higher than those in the observation group(P<0.05).After treatment,there was no statistically significant difference in adverse reactions such as chest tightness,rash,skin swelling,epistaxis,nasal irritation,nasal dryness,and headache between the two groups(P>0.05).Conclusion:The treatment of children with persistent allergic rhinitis by the combination of two kinds of drugs,eugenol and methylpheniramine nasal spray and nasal hormone,can significantly improve the therapeutic effect,improve the quality of sleep,and has high safety,which has clinical value.

关 键 词：儿童持续性变应性鼻炎 色甘萘甲那敏鼻喷雾剂 鼻用激素 睡眠质量 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]