Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies  

作　　者：Yingying Hou Min Chen Yuan Bian Xi Zheng Rongsheng Tong Xun Sun 

机构地区：[1]Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China [2]Personalized Drug Therapy Key Laboratory of Sichuan Province,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China [3]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第8期3321-3338,共18页药学学报(英文版)

基　　金：supported by the Key Research and Development Program of Science and Technology Department of Sichuan Province(No.2019YFS0514);Young Talents Project of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital(No.2022QN08)。

摘　　要：Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide.Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.Nevertheless,the adaptive immune responses of subunit vaccines are still unfavorable,which may partially be attributed to the immune cascade obstacles and unsatisfactory vaccine design.An extended understanding of the crosstalk between vaccine delivery strategies and immunological mechanisms could provide scientific insight to optimize antigen delivery and improve vaccination efficacy.In this review,we summarized the advanced subunit vaccine delivery technologies from the perspective of vaccine cascade obstacles after administration.The engineered subunit vaccines with lymph node and specific cell targeting ability,antigen cross-presentation,T cell activation properties,and tailorable antigen release patterns may achieve effective immune protection with high precision,efficiency,and stability.We hope this review can provide rational design principles and inspire the exploitation of future subunit vaccines.

关 键 词：Subunitvaccine Vaccinedesign Lymph nodetargeting Dendriticcell subset targeting B cell modulation Antigencross-presentation T cell activation Antigenreleasekinetics 

分 类 号：R73[医药卫生—肿瘤]