超声次谐波辅助压力估测技术的影响因素  

Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology

作　　者：张艳芬 郑帅 陈治光 程令刚[1] 汪洪斌 李睿 张雨康 张巍[1] 何文[1] Zhang Yanfen;Zheng Shuai;Chen Zhiguang;Cheng Linggang;Wang Hongbin;Li Rui;Zhang Yukang;Zhang Wei;He Wen(Department of Ultrasound,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;Department of Ultrasound Diagnosis,The Affiliated Changsha Central Hospital,Hengyang Medical School,University of South China,Changsha 410007,China)

机构地区：[1]首都医科大学附属北京天坛医院超声科,北京100050 [2]南华大学衡阳医学院附属长沙中心医院超声诊断科,长沙410007

出　　处：《首都医科大学学报》2023年第6期953-958,共6页Journal of Capital Medical University

摘　　要：目的探讨超声次谐波辅助压力估测(subharmonic-aided pressure estimation,SHAPE)技术的影响因素。方法在水槽内构建一个动态流量的体外模拟实验。通过SHAPE技术采集不同机械指数(mechanical index,MI)、超声造影剂浓度及流速下的次谐波幅度值共3600个,绘制总拟合曲线,量化与压力相关的次谐波幅度快速增长阶段的MI范围及次谐波幅度范围、最佳超声造影剂浓度及流速,明确SHAPE技术应用中的影响因素。结果①与压力相关的次谐波快速增长阶段:MI范围为0.04~0.38,次谐波幅度范围-61.94~-12.82 dB;②快速增长阶段,不同浓度及流速下,次谐波幅度差异有统计学意义(P<0.05);在其他参数一定的情况下,不同浓度、流速和MI下的次谐波幅值最大差异分别为-10.0 dB、-12.84 dB和35.96 dB;③造影剂浓度为3.2μL/100 mL,流速为8μL/min时,次谐波幅度与MI的相关系数最高(r=0.973);④增加相同的MI,不同浓度及流速间次谐波幅度变化的相对值进行比较,均无统计学意义(P>0.05),其中MI相差0.04,次谐波幅度相对值均值约(3.18±1.55)dB,95%可信区间:2.80~3.56 dB;⑤MI的增加导致次谐波幅增加值从9 dB逐渐减小到0.31 dB。结论与声压相关的MI范围及次谐波幅度范围,超声造影剂浓度及流速对SHAPE技术有影响,明确及量化这些影响因素,提高了SHAPE测压的准确性和有效性。Objective To explore the factors influencing the ultrasonic subharmonic-aided pressure estimation(SHAPE)technology.Methods An in vitro simulation of dynamic flow was constructed in a water tank.Three thousand and six hundred subharmonic amplitudes under different mechanical index(MI),sonazoid ultrasound contrast agent concentrations,and flow rates were obtained by SHAPE.The MI and subharmonic amplitude ranges during the pressure-related subharmonic rapid growth stage,the optimal ultrasound contrast agent concentration,and flow rate were quantified using a total fitting curve.Results The MI and sub-harmonic amplitude ranges were 0.04-0.38 and-61.94--12.82 dB,respectively.When the other parameters were constant,the maximum differences of the subharmonic amplitude under different concentrations,flow rates,and MIs were-10.0 dB,-12.84 dB,and 35.96 dB,respectively.The subharmonic amplitude and MI demonstrated the strongest correlation(r=0.973)when the contrast agent concentration and flow rate were 3.2μL/100 mL and 8μL/min,respectively.With MI difference of 0.04,the mean relative subharmonic amplitude was(3.18±1.55)dB(95%CI:2.80-3.56).Under the same concentration and flow rate,the increase of MI caused a gradual decrease in the subharmonic amplitude from 9 dB to 0.31 dB.Conclusion Identification and quantification of the influencing factors may improve the accuracy and effectiveness of SHAPE.

关 键 词：次谐波辅助压力估计技术 次谐波幅度 超声造影剂 影响因素 

分 类 号：R-33[医药卫生]