血浆中成分与孤独症谱系障碍患儿睡眠障碍的关系  

Correlations between serum components and sleep disorders in children with autism spectrum disorder

作　　者：丁文珺 金剑 丁文聪 原阳阳 岳晏如 DING Wen-jun;JIN Jian;DING Wen-cong;YUAN Yang-yang;YUE Yan-ru(不详;The Third Affiliated Hospital of Zhengzhou University(Maternal and Child Health Hospital of Henan Province),Zhengzhou 450052,Henan,China)

机构地区：[1]郑州大学第三附属医院(河南省妇幼保健院)科研中心,河南郑州450052 [2]南华大学附属南华医院神经外科,河南郑州421002

出　　处：《广东医学》2023年第11期1374-1377,共4页Guangdong Medical Journal

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20190338)。

摘　　要：目的 探讨孤独症谱系障碍(autism spectrum disorder, ASD)患儿血液成分与睡眠障碍的关系。方法 2019年1月至2022年12月ASD患者和健康对照组患者,入组时收集人口统计学特征。收集患者的血液样本,ELISA检测患者血浆orexin水平。采用独立样本t检验分析ASD患者和对照组、轻度ASD患者和重度ASD患者orexin水平,spearman分析orexin水平与ASD评分及睡眠分数的相关性,受试者工作特征(ROC)曲线分析orexin水平对ASD患者的预测价值。结果 与对照组比较,ASD组的血浆orexin水平较高(P<0.05)。与轻度ASD组比较,重度ASD患者orexin水平较高(P<0.05);与睡眠良好组患者比较,睡眠不良组的血浆orexin水平较高(P<0.05)。Spearman分析发现orexin水平与ASD评分呈正相关(r=0.887,P<0.001),orexin水平与睡眠分数呈负相关(r=-0.821,P<0.001)。ROC曲线分析重度ASD组orexin水平的曲线下面积(AUC)为0.675,差异有统计学意义(P<0.05)。结论 本研究表明ASD患儿orexin水平较高,且与其严重程度成正相关,并具有一定的预后价值。Objective To investigate the correlation between blood components and sleep disturbance in children with autism spectrum disorder(ASD).Methods ASD patients and healthy control subjects were recruited from January 2019 to December 2022.Demographic characteristics were collected upon enrollment.Blood samples were obtained from patients,and plasma orexin levels were measured using ELISA.Independent sample t-tests were used to analyze plasma orexin levels in ASD patients compared to the control group,as well as in mild and severe ASD patients.Spearman correlation analysis was performed to examine the relationship between orexin levels,ASD scores,and sleep scores.Receiver operator characteristics(ROC)curve analysis was conducted to assess the predictive value of orexin levels for ASD patients.Results Plasma orexin levels were higher in the ASD group compared to the control group(P<0.05).Severe ASD patients had higher orexin levels compared to mild ASD patients(P<0.05).Serum orexin levels were higher in the poor sleep group than in the good sleep group(P<0.05).Spearman correlation analysis showed a positive correlation between orexin levels and ASD scores(r=0.887,P<0.001),and a negative correlation between orexin levels and sleep scores(r=-0.821,P<0.001).The ROC curve analysis revealed an area under ROC curve(AUC)of 0.675 for orexin levels in severe ASD patients,which was statistically significant(P<0.05).Conclusion This study suggests that children with ASD have elevated orexin levels that correlate with the severity of their condition.Moreover,orexin levels hold predictive value for the prognosis of ASD patients.

关 键 词：孤独症谱系障碍 血浆orexin 睡眠障碍 相关性 

分 类 号：R741[医药卫生—神经病学与精神病学] R741[医药卫生—临床医学] R749.94