单硝酸异山梨酯联合β受体阻滞剂对急性心肌梗死的影响  

Effect of Isosorbide Mononitrate Combined withβ-blockers on Acute Myocardial Infarction

作　　者：刘小丽 张玉德 LIU Xiao-li;ZHANG Yu-de(Pharmacy Department of Yima People's Hospital,Yima,Henan,472300,China)

机构地区：[1]义马市人民医院药剂科,河南义马472300

出　　处：《承德医学院学报》2023年第6期476-480,共5页Journal of Chengde Medical University

摘　　要：目的探究单硝酸异山梨酯联合β受体阻滞剂对急性心肌梗死患者血清H-FABP、GDF-15水平的影响。方法选取2019年2月~2020年2月期间于河南省义马市人民医院接受治疗的108例急性心肌梗死患者,根据奇偶数分组法将其分为β受体阻滞剂组及联合治疗组,每组54例。β受体阻滞剂组采用β受体阻滞剂进行治疗,联合治疗组在其基础上加服单硝酸异山梨酯进行治疗。检测LVEF、LVEDD、LVPFR、CK、ET-1、NT-pro BNP、s ICAM-1、IL-6、hs-CRP、GDF-15、H-FABP水平。观察并比较2组患者不良反应发生情况。结果与β受体阻滞剂组相比,联合治疗组LVEF、LVPFR水平较高,LVEDD、心肌梗死标志物、炎性因子、H-FABP、GDF-15水平较低(P<0.05);联合治疗组总不良反应发生情况高于β受体阻滞剂组(P>0.05)。结论单硝酸异山梨酯联合β受体阻滞剂可有效改善急性心肌梗死患者临床症状,促进心功能恢复正常,降低心肌梗死标志物指标水平,其机制可能与降低H-FABP、GDF-15水平相关。Objective To explore the effect of isosorbide mononitrate combined withβ-blocker on the serum levels of H-FABP and GDF-15 in patients with acute myocardial infarction.Methods A total of 108 patients with acute myocardial infarction treated in Yima People's Hospital of Henan Province from February 2019 to February 2020 were selected and divided intoβ-blocker group and combined treatment group according to odd-even grouping method,with 54 cases in each group.Theβ-blocker group was treated withβ-blockers,and the combination group received isosorbide mononitrate on its basis.The levels of LVEF,LVEDD,LVPFR,CK,ET-1,NT-proBNP,sICAM-1,IL-6,hs-CRP,GDF-15,and H-FABP were measured.The occurrence of adverse reactions between the two groups was observed and compared.Results Compared with theβ-blocker group,the combination group had higher level ofLVEF,LVPFR,LVEDD,inflammatory factor H-FABP,GDF-15(P<0.05);the total adverse effects in the combined treatment group were higher than those in theβ-blocker group(P>0.05).Conclusion Isosorbide mononitrate combined withβ-blockers can effectively improve the clinical symptoms of patients with acute myocardial infarction,promote the return of heart function to normal,and reduce the levels of myocardial infarction markers.The mechanism may be related to the reduction of H-FABP and GDF-15 levels.

关 键 词：单硝酸异山梨酯 Β受体阻滞剂 急性心肌梗死 心肌脂肪酸结合蛋白 

分 类 号：R734.2[医药卫生—肿瘤]