口腔黏膜下纤维性变癌变的分子机制研究进展  

Advances in molecular mechanisms of oral submucosal fibrogenic carcinogenesis

作　　者：李冰霞 温琦涛 王涛 孙冠宇[1,2] 符骁 苏守达 LI Bing-xia;WEN Qi-tao;WANG Tao;SUN Guan-yu;FU Xiao;SU Shou-da(School of Stomatology,Hainan Medical University,Haikou 571199,China;Department of Stomatology,Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南医学院口腔医学院,海南海口571199 [2]海南省人民医院口腔科,海南海口570311

出　　处：《海南医学院学报》2023年第23期1836-1840,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金(81960199);海南省重大科技计划、省重点研发计划项目(ZDYF2021SHFZ114);海南省卫生厅项目(22A200001)。

摘　　要：口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是一种慢性进行性、隐匿性的口腔黏膜疾病。它的发展与咀嚼槟榔高度相关,最终向口腔鳞状细胞癌演变,目前被国际癌症研究中心认定为癌前状态。由于OSF癌变过程极其复杂,癌变机制尚不明确,多数学者认为该病为多种因素共同影响的结果。因此,本文主要对OSF癌变的分子机制最新研究进行归纳总结,旨在了解OSF癌变规律,为早发现、早诊断、早治疗OSF癌变提供理论参考,为后期基础研究、临床治疗提供分子治疗依据。Oral submucous fibrosis(OSF)is a chronic,progressive and insidious oral mucosal disease.Its development is highly associated with areca chewing and eventually evolves into oral squamous cell carcinoma(OSCC),which is currently recog⁃nized as a precancerous state by the International Agency for Research on Cancer(IARC).Due to the extremely complex carcino⁃genesis process of OSF,the carcinogenesis mechanism is not clear,and most scholars believe that the disease is the result of multi⁃ple factors.Therefore,this paper mainly summarized the latest research on the molecular mechanism of OSF cancerization,aiming at understanding the law of OSF cancerization and providing theoretical reference for early detection,diagnosis and treatment of OSF cancerization.

关 键 词：口腔黏膜下纤维性变 癌变 机制 

分 类 号：R739.8[医药卫生—肿瘤]