Vimentin在常见妇科恶性肿瘤中的研究进展  

Research Progress of Vimentin in Common Gynecological Malignancies

作　　者：武霞 晋雨楠 范裕裕 索玉平[2] WU Xia;JIN Yu-nan;FAN Yu-yu;SUO Yu-ping(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,China;Department of Obstetrics and Gynecology,Shanxi Provincial People′s Hospital,Taiyuan 030012,China)

机构地区：[1]山西医科大学第五临床医学院,太原030012 [2]山西省人民医院妇产科

出　　处：《国际妇产科学杂志》2023年第6期655-659,共5页Journal of International Obstetrics and Gynecology

摘　　要：波形蛋白(Vimentin)是一种重要的Ⅲ型中间丝蛋白,主要来源于间叶细胞。Vimentin在多种类型肿瘤中表达,其表达上调与肿瘤细胞迁移和侵袭能力有关,提示患者预后较差。Vimentin是肿瘤细胞上皮-间质转化的典型标志物,是潜在的药物靶点。研究表明,Vimentin在宫颈癌、卵巢癌和子宫内膜癌中均异常表达,且与患者的预后、转移和复发有关,具有潜在的临床应用价值。综述Vimentin与妇科恶性肿瘤的关系及可能机制。Vimentin is an important typeⅢintermediate filament protein,mainly derived from mesenchymal cells.Vimentin is expressed in various types of tumors,and up-regulated expression of Vimentin is related to the migration and invasion ability of tumor cells,suggesting poor prognosis.Vimentin is a typical marker of epithelial-mesenchymal transition of tumor cells and a potential drug target.Studies have shown that Vimentin is abnormally expressed in cervical cancer,ovarian cancer and endometrial cancer,and is related to prognosis,tumormetastasis and recurrence,which has potential clinical application value.This article reviews the relationship between Vimentin as well as gynecological malignancy and its possible mechanism.

关 键 词：波形蛋白 宫颈肿瘤 卵巢肿瘤 子宫内膜肿瘤 预后 

分 类 号：R737.3[医药卫生—肿瘤]