控压引流联合尿激酶注入在脑出血微创治疗中的临床研究  

Clinical study of pressure-controlled drainage combined with Urokinase injection in minimally invasive treatment of cerebral hemorrhage

作　　者：马志东[1] 蔡立娟[1] 孙景志[1] MA Zhidong;CAI Lijuan;SUN Jingzhi(Department of Neurosurgery,Songyuan Central Hospital,Jilin Province,Songyuan138000,China)

机构地区：[1]吉林省松原市中心医院神经外科,吉林松原138000

出　　处：《中国当代医药》2023年第34期59-63,共5页China Modern Medicine

基　　金：吉林省卫生健康科技能力提升项目(2021LC087)。

摘　　要：目的分析控制压力下引流联合尿激酶注入治疗脑出血的效果。方法选取2021年5月至2023年5月吉林省松原市中心医院收治的80例幕上自发性脑出血(ICH)患者作为研究对象,按奇偶数分组法随机分为研究组和对照组,每组各40例。研究组患者采用微创置管引流后控制引流压力下间断注入尿激酶引流,对照组患者采用微创置管引流后零压力下间断注入尿激酶引流。比较两组患者的血肿清除时间、意识障碍改善时间、再出血例数、在医院的诊疗时间和格拉斯哥预后评分(GOS)。结果研究组患者的颅内血肿清除时间和诊疗时间短于对照组,差异有统计学意义(P<0.05)。两组患者的意识障碍改善时间和再出血例数比较,差异无统计学意义(P>0.05)。研究组患者的GOS预后评分指标优于对照组,差异有统计学意义(P<0.05)。结论控压引流联合尿激酶注入能明显增强引流效果,缩短病程,减少住院天数,易于推广,适用于广大基层医院。Objective To analyze the efficacy of pressure-controlled drainage combined with Urokinase injection in the treatment of cerebral hemorrhage.Methods Eighty patients with supratentatal spontaneous intracerebral hemorrhage(ICH)who were admitted to Songyuan Central Hospital,Jilin Province from May 2021 to May 2023,were selected as the study objects,and randomly divided into study group and control group according to odd-even group method,with 40 cases in each group.In the study group,Urokinase drainage was injected intermittently under pressure-controlled drainage after minimally invasive catheter drainage,while in the control group,Urokinase drainage was injected intermittently under zero pressure after minimally invasive catheter drainage.The time of hematoma clearance,the time of improvement of consciousness disturbance,the number of rebleeding cases,the time of diagnosis and treatment in hospital and the Glasgow outcome scale(GOS)were compared between the two groups.Results The clearance time and hospital diagnosis and treatment time of intracranial hematoma in the study group were shorter than those in the control group,with statistical significances(P<0.05).There were no statistically significant differences in the improvement time of disturbance of consciousness and the number of rebleeding cases between the two groups(P>0.05).GOS prognosis score of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of pressure-controlled drainage and Urokinase injection can significantly enhance the drainage effect,shorten the course of disease,reduce hospital stay,and is easy to promote.It is applicable for grassroots hospitals.

关 键 词：自发性脑出血 控压引流 微创置管引流 尿激酶 

分 类 号：R743.34[医药卫生—神经病学与精神病学]