靶向Nrf2信号通路的神经保护作用研究进展  

The Advance of Neuroprotective Effects on Targeting Nrf2 Signaling Pathway

作　　者：张思锐 张嫚嫚 孙若男 王丹[1] ZHANG Sirui;ZHANG Manman;SUN Ruonan;WANG Dan(Medical College,Dalian University,Dalian 116622,China)

机构地区：[1]大连大学医学院,辽宁大连116622

出　　处：《生物化工》2023年第5期174-179,共6页Biological Chemical Engineering

基　　金：辽宁省大学生创新创业训练计划项目(S202211258038)。

摘　　要：Nrf2作为调控抗氧化应激的一种关键转录因子,是机体抗氧化应答反应的核心,其主要通过经典的Keap1-Nrf2-ARE信号通路及其调控的下游靶基因来减少氧化应激损伤,从而实现神经保护作用。目前有研究表明Nrf2的激活在多种中枢神经系统疾病中发挥着重要作用,如癫痫、中枢神经退行性疾病和脑血管疾病等,本文综述了以Nrf2信号通路为靶点的神经保护作用,以期在今后相关疾病的治疗中发掘潜在药物靶点,为这些疾病的临床治疗提供新思路。Nrf2,as a key transcription factor regulating antioxidant stress,is the core of the body’s antioxidant response.Nrf2 primarily reduces oxidative stress damage through the classic Keap1-Nrf2-ARE signaling pathway and its regulated downstream target genes,so as to achieve neuroprotection.At present,studies have shown that Nrf2 activation plays an important role in numerous central nervous system diseases,such as epilepsy,central neurodegenerative diseases and cerebrovascular diseases.Therefore,this paper reviews the research progress on the neuroprotective effects of Nrf2 signaling pathway,in order to explore potential drug targets in the treatment of related diseases in the future and provide new ideas for clinical treatment of these diseases.

关 键 词：NRF2 神经保护 癫痫 神经退行性疾病 脑血管性疾病 

分 类 号：R742[医药卫生—神经病学与精神病学]