子宫肌瘤在注入氨甲喋呤后的组织形态学观察  

Observation of the Womb Myoma Tissue Morphology After MTX Injection

作　　者：苑洪菲[1] 王晓蓉[1] 王联连[1] 张萍[1] 崔红艳[1] 

机构地区：[1]武警黑龙江省总队医院妇产科,黑龙江哈尔滨150076

出　　处：《黑龙江医学》2002年第11期829-830,共2页Heilongjiang Medical Journal

摘　　要：目的　探讨子宫肌瘤在注入氨甲喋呤 (MTX)后缩小的机制。方法　对 5例子宫肌瘤在注入MTX 2周及 1个月后行手术治疗 ,对其标本进行光镜和电镜观察 ,并与同期未注药标本进行比较。结果　所有注入MTX的标本光镜下 ,均可见明显的平滑肌细胞的水肿、变性。电镜下见平滑肌细胞内变性、水肿 ,扩张的内质网和线粒体等。结论　MTX的缩瘤效果是通过减少肌瘤内的血供和直接的细胞凋亡来完成的。Objective To investigate the mechanism of womb myoma shrinkage after methotrexate (MTX) injection. Methods Operations were performed in 5 womb myoma patients at half month and one month respectively after MTX injection. The specimens were observed through light microscope and electron microscope. The results were compared with that of control group. Results In MTX injection group, smooth muscle cell edema and degeneration could be seen by light microscope and electron microscope; endoplasmic reticulum and mitochondrion extension could be seen in smooth muscle cell by electron microscope. Conclusion MTX shrink womb myoma by reducing the blood supply of myoma and causing apoptosis

关 键 词：子宫肌瘤 氨甲喋呤 组织形态学 药物治疗 超微结构 治疗 

分 类 号：R737.33[医药卫生—肿瘤]