CTCs、IGF-1R及RNPC1对非小细胞肺癌患者术后复发的预测价值  

Predictive value of CTCs,IGF ⁃ 1R and RNPC1 for postoperative recurrence in patientswith non⁃small cell lung cancer

作　　者：李娜[1] 于宏彬 张茜[1] 叶鑫[1] LI Na;YU Hongbin;ZHANG Qian;YE Xin(Department of Thoracic Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing,China,100020)

机构地区：[1]首都医科大学附属北京朝阳医院胸外科,北京100020

出　　处：《分子诊断与治疗杂志》2023年第10期1733-1736,共4页Journal of Molecular Diagnostics and Therapy

基　　金：北京市医学科技攻关计划项目(719918215)。

摘　　要：目的 分析循环肿瘤细胞(CTCs)、胰岛素样生长因子1(IGF-1R)及RNA结合蛋白(RNPC1)对非小细胞肺癌(NSCLC)患者术后复发的预测价值。方法 选取2021年4月至2022年1月于首都医科大学附属北京朝阳医院进行肺切除术手术治疗的NSCLC患者132例为研究对象。总结12个月后随访情况;比较手术前后CTCs、IGF-1R、RNPC1水平变化情况;分析影响NSCLC患者术后复发的单因素,采用多元Logistic回归分析CTCs、IGF-1R、RNPC1对NSCLC患者术后复发的相关因素。结果患者术后CTCs、IGF-1R、RNPC1测量值均低于术前,差异有统计学意义(P<0.05);经随访发现,复发转移组45例,非复发转移组87例;两组性别、年龄、BMI、高血压史、糖尿病史、吸烟比较差异无统计学意义(P>0.05)。两组TNM分期、分化程度与CTCs、IGF-1R、RNPC1测量值比较差异具有统计学意义(P<0.05);经Logistic回归分析显示:TNM分期为Ⅲ~Ⅳ期、分化程度为中低分化、CTCs>14.05±11.73个/mL、IGF-1R>256.39±23.47μg/L、RNPC1>0.89±0.12 IU/mL均是影响NSCLC患者术后复发的危险因素(P<0.05)。结论 CTCs、IGF-1R、RNPC1水平在NSCLC术后均明显下降,对预后评估具有重要的指导价值;因此,可将CTCs、IGF-1R、RNPC1水平作为评估NSCLC患者术后复发转移的重要参考依据。Objective To analyze the predictive value of circulating tumor cells(CTCs),insulin-like growth factor 1 receptor(IGF-1R)and RNA binding protein(RNPC1)on the postoperative recurrence in non-small-cell lung cancer(NSCLC)patients.Methods A total of 132 patients with NSCLC who underwent pulmonary resection in our hospital from April 2021 to January 2022 were selected as the study objects.The comparison of CTCs,IGF-1R,and RNPC1 measurement values before and after operation was analyzed.The single factor affecting postoperative recurrence of NSCLC patients was analyzed.Multivariate Logistic regression was used to analyze the multiple factors of CTCs,IGF-1R and RNPC1 on the recurrence of NSCLC patients.Results The postoperative CTCs,IGF-1R,and RNPC1 measurements of patients were lower than those before surgery,with statistically significant differences(P<0.05).After follow-up,there were 45 cases in the recurrence and metastasis group,and 87 cases in the non-relapse and metastasis group.There was no significant difference in gender,age,BMI,history of hypertension,history of diabetes,and smoking between the two groups(P>0.05).The TNM stage,degree of differentiation and the measurement values of CTCs,IGF-1R,and RNPC1 in the two groups were statistically significant(P<0.05).Logistic regression analysis showed that The TNM stages wereⅢ-Ⅳ,the differentiation degree was medium to low,CTCs>14.05±11.73/mL,IGF-1R>256.39±23.47μg/L,RNPC 1>0.89±0.12 IU/mL were all risk factors for postoperative recurrence in NSCLC patients(P<0.05).Conclusion The levels of CTCs,IGF-1R and RNPC1 are significantly decreased after NSCLC surgery,which has important guiding value for prognosis evaluation.Therefore,the levels of CTCs,IGF-1R and RNPC1 can be used as an important reference for evaluating postoperative recurrence and metastasis in patients with NSCLC.

关 键 词：CTCS IGF-1R RNPC1 非小细胞肺癌 术后复发 

分 类 号：R734.2[医药卫生—肿瘤]