TVCDS联合ki-67、AFU及AFP检测在卵巢肿瘤性质诊断中的应用价值  

The value of TVCDS combined with ki⁃67,AFU,and AFP detection in the diagnosis of ovarian tumor properties

作　　者：蒋霞 侯莉 赵晶 李金燕 方敏 JIANG Xia;HOU Li;ZHAO Jing;LI Jinyan;FANG Min(Department of Special Examination,Dezhou Women and Children's Hospital(Dezhou Maternal and Child Health Hospital),Dezhou,Shandong,China,253015;Department of Laboratory Medicine,Dezhou Women and Children’s Hospital(Dezhou Maternal and Child Health Hospital),Dezhou,Shandong,China,253015)

机构地区：[1]德州市妇女儿童医院(德州市妇幼保健院)特检科,山东德州253015 [2]德州市妇女儿童医院(德州市妇幼保健院)检验科,山东德州253015

出　　处：《分子诊断与治疗杂志》2023年第10期1737-1740,1744,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山东省卫生健康委员会资助项目(2020WS6132)。

摘　　要：目的 分析经阴道彩色多普勒超声(TVCDS)联合细胞核增殖抗原(ki-67)、α-L-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)检测在卵巢肿瘤性质诊断中的应用价值。方法 收集2020年1月至2023年3月德州市妇女儿童医院收治的200例卵巢肿瘤患者的临床资料,所有患者均进行病理检查、TVCDS检查等。获取患者病理检查结果,对比良、恶性患者血清ki-67、AFU、AFP水平及TVCDS检测中血管分型、血流参数,并分析TVCDS、ki-67、AFU、AFP单独及联合诊断对卵巢肿瘤性质的鉴别诊断效能。结果200例患者中恶性16例,良性184例。恶性组ki-67阳性率、AFU、AFP水平均明显高于良性组,差异有统计学意义(P<0.05);良、恶性患者TVCDS血管分型情况比较差异有统计学意义(P<0.05),其中恶性组患者以3型(68.75%)为主,良性组则以1型为主(65.76%);恶性组患者PSV、EDV值均高于良性组,而RI值则明显低于良性组,差异有统计学意义(P<0.05);联合检测与病理检查结果几乎完全一致(Kappa=0.851),TVCDS、AFP一致性中等(Kappa=0.560,Kappa=0.480)、AFU、ki-67一致性一般(Kappa=0.291,Kappa=0.358);联合检测对卵巢肿瘤良、恶性诊断准确度为97.50%、灵敏度为97.28%、特异度76.19%,高于TVCDS、ki-67、AFU、AFP单独检测(P<0.05)。结论 TVCDS联合血清ki-67、AFU及AFP检测可提高卵巢肿瘤性质鉴别的准确度、灵敏度及特异度,降低漏诊及误诊风险。Objective To analyze the diagnostic value of transvaginal color Doppler ultrasound(TVCDS)combined with nuclear proliferating antigen(ki-67).α-L-fucosidase(AFU)and alpha fetoprotein(AFP)detection in the diagnosis of benign and malignant ovarian tumors.Methods Clinical data of 200 ovarian tumor patients admitted to Dezhou Women and Children's Hospital from January 2020 to March 2023 were collected,and all patients underwent pathological and TVCDS examinations.The pathological examination results of patients were obtained,andthe serum levels of ki-67,AFU,and AFP in benign and malignant patients,and the vascular classification and blood flow parameters in TVCDS testing were compared.The differential diagnostic efficacy of TVCDS,ki-67,AFU,and AFP alone and in combination for the nature of ovarian tumors was analyzed.Results The pathological examination showed that among the 200 patients,16 were malignant and 184 were benign.The positive rate of ki-67,AFU,and AFP levels in the malignant group were significantly higher than those in the benign group,and the difference was statistically significant(P<0.05).There was a statistically significant difference in TVCDS vascular typing between benign and malignant patients(P<0.05),in the malignant group,type 3(68.75%)was the main type,while in the benign group,type 1(65.76%)was the main type.The PSV and EDV values of patients in the malignant group were higher than those in the benign group,while the RI values were significantly lower than those in the benign group,and the difference was statistically significant(P<0.05).The results of combined testing and pathological examination were almost identical(Kappa=0.851),TVCDS and AFP had moderate consistency(Kappa=0.560,Kappa=0.480),and AFU and ki-67 had moderate consistency(Kappa=0.291,Kappa=0.358).The accuracy,sensitivity,and specificity of combined detection for the diagnosis of benign and malignant ovarian tumors were 97.50%,97.28%,and 76.19%,respectively,higher than those of TVCDS,ki-67,AFU,and AFP alone(P<0.05).Conclusion TVC

关 键 词：彩色多普勒超声 细胞核增殖抗原 Α-L-岩藻糖苷酶 甲胎蛋白 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]