碘介导下通过氧化性C—C键形成合成β-硝基胺与α-胺基腈类化合物  

Synthesis ofβ-Nitroamines andα-Aminonitriles by I2-Mediated Oxidative C—C Bond Formation

作　　者：李倩敏 王漫漫 于文全[1] 常俊标[1] Li Qianmin;Wang Manman;Yu Wenquan;Chang Junbiao(Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001;School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]郑州大学化学学院绿色催化中心,郑州450001 [2]郑州大学化工学院绿色催化中心,郑州450001

出　　处：《有机化学》2023年第11期3966-3976,共11页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Henan Province Epidemic Prevention and Control Emergency Research Project(No.221111311400);the Young Backbone Teachers Fund of Henan Province(No.2021GGJS012);the National Natural Science Foundation of China(No.82130103)。

摘　　要：以分子碘为单一氧化剂,开发了一种无过渡金属催化的C—C键形成反应.该反应可通过易得的叔胺分别与硝基烷、三甲基氰硅烷和亚磷酸酯合成β-硝基胺、α-胺基腈和α-胺基膦酸酯类化合物.该合成方法具有操作简单,底物适用范围广,而且可以成功实现克级规模的合成.A transition-metal-free C—C bond formation reaction is developed employing molecular iodine as the sole oxidant to accessβ-nitroamines,α-aminonitriles andα-aminophosphonates from readily accessible tertiary amines with nitroalkanes,trimethylsilyl cyanide and phosphite,respectively.The present synthetic approach is operationally simple,has a broad substrate scope,and can be successfully conducted on a gram scale.

关 键 词：碘 C—C键形成 叔胺 β-硝基胺 α-胺基腈 

分 类 号：O623.7[理学—有机化学]