小剂量阿片类药物过量病例报道  

Two cases of overdose caused by low dose opioids

作　　者：邓芳 黄莉 DENG Fang;HUANG Li(Department of Pathology,The First Affiliated Hospital of University of South China,Hengyang 421000,Hunan,China;Department of Medical Oncology,The Second Affiliated Hospital of University of South China,Hengyang 421000,Hunan China)

机构地区：[1]南华大学附属第一医院病理科,湖南衡阳421000 [2]南华大学附属第二医院肿瘤中心一区,湖南衡阳421000

出　　处：《中国药物依赖性杂志》2023年第5期490-494,共5页Chinese Journal of Drug Dependence

基　　金：湖南省卫健委一般指导课题(202214015306)。

摘　　要：目的报道两例小剂量阿片类药物引起过量的病例,为临床阿片类药物过量的预估及诊治提供参考。方法回顾性分析两例服用小剂量盐酸羟考酮缓释片发生过量患者的临床资料,查阅文献,分析该两例患者的临床表现及存在的危险因素。结果服用小剂量阿片类药物也可能发生过量,缓释制剂和高龄是可能的风险因素。结论口服小剂量阿片药物也应警惕过量的发生,如合并其他危险因素更应引起重视,防止不良事件发生。Objective This paper reports two cases of overdose caused by taking small dose of opioids,providing reference for the prediction,diagnosis and treatment of clinical opioids overdose.Methods The clinical data of two patients with overdose after taking small dose of oxycodone hydrochloride sustained-release tablets were retrospectively analyzed.The clinical feature and risk factors of the two patients were analyzed by literature review.Results Taking small doses of opioids may cause overdose,and sustained-release preparations and older age are possible risk factors.ConclusionnThe use of small doses of opioids should also be vigilant against the occurrence of overdose.If combined with other risk factors,more attention should be paid to prevent adverse events.

关 键 词：盐酸羟考酮缓释片 阿片类药物 小剂量 药物过量 

分 类 号：R749[医药卫生—神经病学与精神病学]