穴区结缔组织在针刺效应启动中的作用机制研究进展  

Research Progress on the Role and Mechanism of Connective Tissue in the Initiation of Acupuncture Effects in Acupoint Areas

作　　者：付疆疆 林小伟 窦报敏 李艳伟 樊泽至 刘琪 郭义[2] FU Jiangjiang;LIN Xiaowei;DOU Baomin;LI Yanwei;FAN Zezhi;LIU Qi;GUO Yi(School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Chinese Medical College,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学针灸推拿学院,天津301617 [2]天津中医药大学实验针灸学研究中心,天津301617 [3]天津中医药大学中医学院,天津301617

出　　处：《世界中医药》2023年第20期2988-2992,共5页World Chinese Medicine

基　　金：国家自然科学基金重点基金项目(82030125);国家自然科学基金青年科学基金项目(82105024);天津市科技计划项目(20JCQNJC00280);天津市卫生健康委员会青年项目(2021056)。

摘　　要：穴区作为针刺的初始应答部位,是针效的源头。针刺引起穴区微环境的变化是其发挥效应的关键启动环节,阐明针刺的启动机制可进一步推动针刺临床应用。通过对针刺穴区相关基础研究文献进行梳理,发现针刺后穴区微环境结缔组织的变化与针刺效应密切相关,结缔组织中成纤维细胞、肥大细胞和巨噬细胞在针刺效应启动过程中发挥了重要作用,但有关针刺穴位启动机制的基础研究零散、不系统,针刺穴位启动机制的研究可为针刺临床应用提供依据,未来仍有很大深入研究的空间。The acupoint area,as the initial response site to acupuncture,is the origin of acupuncture effect.The change in the acupoint microenvironment caused by acupuncture is the key initiating step for the manifestation of its effect.Clarifying the initiation mechanism of acupuncture can further promote the clinical application of acupuncture.Through a review of relevant research literature on acupoint acupuncture,this paper finds that the changes in connective tissue in the acupoint microenvironment are closely related to acupuncture effect,and fibroblasts,mast cells and macrophages within the connective tissue play an important role in the initiation of acupuncture effect.However,the basic research on the initiation mechanism of acupuncture at acupoint sites is scattered and not systematic.Further in-depth research on the initiation mechanism of acupuncture at acupoint sites can provide a basis for the clinical application of acupuncture.There is still considerable room for future exploration and research in this area.

关 键 词：针刺 穴区 结缔组织 针刺效应 穴区微环境 成纤维细胞 肥大细胞 巨噬细胞 

分 类 号：R245[医药卫生—针灸推拿学]