免疫三氧自体血回输联合他汀类降脂药物治疗急性缺血性脑血管病的效果及对低密度脂蛋白胆固醇水平的影响  

Effect of ozone autohemotherapy treatment combined with statin lipid-lowering drugs in the treatment of acute ischemic cerebrovascular disease and its influence on low-density lipoprotein cholesterol

作　　者：侯静 李欢 王蕾 李越 张勇 HOU Jing;LI Huan;WANG Lei(Department of Neurology,PLA 92493 Army Hospital,Huludao 125001,China)

机构地区：[1]中国人民解放军92493部队医院神经内科,125001

出　　处：《中国现代药物应用》2023年第22期95-98,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究免疫三氧自体血回输联合他汀类降脂药物治疗急性缺血性脑血管病的效果及对低密度脂蛋白胆固醇水平的影响。方法90例急性缺血性脑血管病患者,采取随机数字表法分为对照组和观察组,每组45例。对照组给予常规治疗联合他汀类降脂药物治疗,观察组在对照组基础上增加免疫三氧自体血回输治疗。对比两组临床疗效、治疗期间不良反应发生情况及治疗前后神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)评分]、日常生活能力量表评分(Barthel指数)、血清低密度脂蛋白胆固醇水平。结果观察组临床总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分、血清低密度脂蛋白胆固醇水平低于本组治疗前,Barthel指数高于本组治疗前,且观察组NIHSS评分(5.44±1.76)分、血清低密度脂蛋白胆固醇(3.25±0.09)mmol/L低于对照组的(8.99±3.21)分、(4.35±0.12)mmol/L,Barthel指数(88.65±7.50)分高于对照组的(76.31±6.54)分,差异均具有统计学意义(P<0.05)。两组治疗期间无明显不良反应发生。结论免疫三氧自体血回输联合他汀类降脂药物治疗急性缺血性脑血管病的临床效果突出,能够显著改善神经缺损程度,提高日常生活能力,调节低密度脂蛋白胆固醇水平,且不会增加不良反应,值得临床推广应用。Objective To investigate the effect of ozone autohemotherapy treatment combined with statin lipid-lowering drugs in the treatment of acute ischemic cerebrovascular disease and its influence on lowdensity lipoprotein cholesterol.Methods A total of 90 patients with acute ischemic cerebrovascular disease were divided into a control group and an observation group according to the random numerical table,with 45 cases in each group.The control group was treated with conventional treatment and statin lipid-lowering drugs,and the observation group was treated with ozone autohemotherapy treatment on the basis of the control group.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions during treatment,the degree of neurological deficit[National Institutes of Health Stroke Scale(NIHSS)score],activities of daily living score(Barthel index)and the serum level of low-density lipoprotein cholesterol before and after treatment.Results The total clinical effective rate of the observation group was 93.33%,which was higher than that of 73.33%of the control group,and the difference was statistically significant(P<0.05).After treatment,NIHSS score and serum level of low-density lipoprotein cholesterol in both groups were lower than those before treatment in this group,and the Barthel index was higher than that before treatment in this group;NIHSS score of(5.44±1.76)points and serum levels of low-density lipoprotein cholesterol of(3.25±0.09)mmol/L in the observation group were lower than those of(8.99±3.21)points and(4.35±0.12)mmol/L in the control group;Barthel index of(88.65±7.50)points in the observation group was higher than that of(76.31±6.54)points in the control group;the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups during treatment.Conclusion Ozone autohemotherapy treatment combined with statin lipid-lowering drugs has outstanding clinical effects in the treatment of acute ischemic cerebrovascular disease,which can significantl

关 键 词：免疫三氧自体血回输 急性缺血性脑血管病 他汀类降脂药物 低密度脂蛋白胆固醇 

分 类 号：R743.3[医药卫生—神经病学与精神病学]